Faculty of Nursing, Université de Montréal, Montréal, Canada.
Research Center of the CHU Sainte-Justine, Montréal, Canada.
Syst Rev. 2017 Nov 3;6(1):225. doi: 10.1186/s13643-017-0613-5.
Previous systematic reviews have examined preterm infants' long-term neurodevelopment after neonatal intensive care unit (NICU) discharge, although none have explored the effectiveness of interventions on preterm infants' neurodevelopment during NICU hospitalization. The aim of this review is to evaluate whether interventions, i.e., sensory stimulation, parental involvement, and control of environment, improve preterm infants' neurodevelopment during their NICU hospitalization.
Experimental studies such as randomized controlled/clinical trials (RCTs) and cluster RCT will be included in this systematic review. Selected studies will be published in English or in French, in the past 15 years from 2002 to 2017. The following electronic databases will be searched to locate relevant studies: CINAHL, MEDLINE, PubMed, EMBASE (OVID), Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science. For all steps in selecting studies, agreement will be reached between two experts in neonatology. Data extraction will be performed independently by the two same experts and will then be compared. The Cochrane assessment tool will be used to screen the studies for risk of bias. A meta-analysis will be performed if the included studies are sufficiently homogeneous. Results will be analyzed using a standardized mean difference (with a 95% confidence interval). Statistical heterogeneity will be evaluated using the χ test at the significance level of 0.1 and the I with the classification suggested by PRISMA-P. If possible, subgroup analyses will be carried out considering preterm infants' gestational age, length of NICU hospitalization, and the characteristics of the intervention such as who delivered it, the type, the dose, the frequency, and the duration. Data synthesis will be performed using the RevMan 5.1 software. Publication bias and selection of variables in publication will be examined using the graphical method of funnel plot and with the statistical test of Egger. Quality of the evidence of all outcomes will be assessed using the Grades of Recommendations Assessment, Development and Evaluation (GRADE) Working Group.
The results of this systematic review will highlight which interventions are effective for promoting preterm infants' neurodevelopment during NICU hospitalization and will contribute to the body of knowledge in neonatal care by providing guidance for NICU clinical practice and research.
PROSPERO CRD42017047072.
之前的系统评价已经研究了新生儿重症监护病房（NICU）出院后早产儿的长期神经发育情况，但没有一项研究探讨过在 NICU 住院期间干预措施对早产儿神经发育的影响。本研究旨在评估感官刺激、父母参与和环境控制等干预措施是否能改善早产儿在 NICU 住院期间的神经发育。
本系统评价将纳入实验研究，如随机对照试验（RCT）和整群 RCT。选择的研究将以英文或法文发表，时间范围为 2002 年至 2017 年的过去 15 年。将检索以下电子数据库以定位相关研究：CINAHL、MEDLINE、PubMed、EMBASE（OVID）、Cochrane 系统评价数据库、Cochrane 对照试验中心注册库（CENTRAL）和 Web of Science。两位新生儿科专家将对研究选择的所有步骤达成一致。两名专家将独立进行数据提取，并进行比较。将使用 Cochrane 评估工具筛选研究的偏倚风险。如果纳入的研究足够同质，将进行荟萃分析。结果将使用标准化均数差（95%置信区间）进行分析。使用 χ 检验评估统计学异质性（显著性水平为 0.1）和 I 检验，并根据 PRISMA-P 建议进行分类。如果可能，将根据早产儿的胎龄、NICU 住院时间和干预措施的特征（如谁提供干预、类型、剂量、频率和持续时间）进行亚组分析。使用 RevMan 5.1 软件进行数据综合。将使用漏斗图的图形方法和 Egger 统计检验检查发表偏倚和发表变量选择。使用推荐评估、制定与评价（GRADE）工作组的 Grades of Recommendations Assessment, Development and Evaluation（GRADE）方法评估所有结局的证据质量。
本系统评价的结果将强调哪些干预措施能有效促进早产儿在 NICU 住院期间的神经发育，并通过为 NICU 临床实践和研究提供指导，为新生儿护理领域的知识体系做出贡献。
PROSPERO CRD42017047072。
