Wertheimer N, Leeper E
Department of Preventive Medicine, University of Colorado Health Sciences Center, Denver 80262.
Am J Epidemiol. 1989 Jan;129(1):220-4. doi: 10.1093/oxfordjournals.aje.a115112.
We have studied two sources of electromagnetic fields where exposure is highly seasonal (ceiling cable electric heat and electrically heated beds). Because many potential confounders could not be addressed, we can make no valid statement about overall differences in abortion rates between those exposed and those not exposed to these seasonal sources. However, by analyzing seasonal trends, we have minimized the problem of unaddressed confounders because we did not look at a difference between the user and nonuser groups, but rather at a difference within the user group during months of higher exposure compared with months of lower exposure. Thus, each user group provides its own control. The function of the nonuser control group is simply to assure that any seasonal trend found in the user group is not just a general seasonal variation in reported fetal loss that can be found equally well in the nonuser population. Using this technique, we found that each user group reported fetal loss disproportionately often during the season when electromagnetic field exposure was increasing.
我们研究了两种电磁场源,其暴露具有高度季节性(天花板电缆电加热和电加热床)。由于许多潜在的混杂因素无法得到解决,我们无法就暴露于这些季节性源的人群与未暴露人群之间流产率的总体差异做出有效的陈述。然而,通过分析季节性趋势,我们将未解决的混杂因素问题降至最低,因为我们没有观察使用者组和非使用者组之间的差异,而是观察使用者组在暴露较高月份与暴露较低月份之间的差异。因此,每个使用者组都提供了自身的对照。非使用者对照组的作用仅仅是确保在使用者组中发现的任何季节性趋势不仅仅是报告的胎儿丢失的一般季节性变化,这种变化在非使用者人群中同样可以很好地发现。使用这种技术,我们发现每个使用者组在电磁场暴露增加的季节报告胎儿丢失的频率不成比例地高。