Faculty of Medicine, University of Turku, Turku, Finland; Cognitive Brain Research Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Basic Psychology, University of Barcelona, Barcelona, Spain; Poeppel Lab, Department of Psychology, New York University, NY, USA.
Cortex. 2017 Dec;97:255-273. doi: 10.1016/j.cortex.2017.09.028. Epub 2017 Oct 10.
Acquired amusia provides a unique opportunity to investigate the fundamental neural architectures of musical processing due to the transition from a functioning to defective music processing system. Yet, the white matter (WM) deficits in amusia remain systematically unexplored. To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA). Non-recovered amusia was associated with structural damage and subsequent degeneration in multiple WM tracts including the right inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF), and frontal aslant tract (FAT), as well as in the corpus callosum (CC) and its posterior part (tapetum). In a linear regression analysis, the volume of the right IFOF was the main predictor of MBEA performance across time. Overall, our results provide a comprehensive picture of the large-scale deficits in intra- and interhemispheric structural connectivity underlying amusia, and conversely highlight which pathways are crucial for normal music perception.
获得性失乐症为研究音乐加工的基本神经结构提供了一个独特的机会，因为这涉及到从正常的音乐加工系统向有缺陷的音乐加工系统的转变。然而，失乐症患者的大脑白质（WM）缺陷仍未得到系统的研究。为了评估哪些 WM 结构构成了获得性失乐症及其恢复的神经基础，我们使用弥散张量成像（DTI [基于束的空间统计学（TBSS）和确定性追踪（DT）]）和失乐症评估蒙特利尔成套测验的音高和节奏分测验，对 42 名脑卒中患者进行了纵向研究，分别在脑卒中后急性期、3 个月和 6 个月进行。非恢复性失乐症与结构损伤以及随后的多个 WM 束退化有关，包括右侧下额枕束（IFOF）、弓状束（AF）、下纵束（ILF）、钩束（UF）和额斜束（FAT），以及胼胝体（CC）及其后部（连合后弓）。在线性回归分析中，右侧 IFOF 的体积是 MBEA 表现的主要预测因子。总的来说，我们的研究结果提供了一幅全面的图景，说明了失乐症患者大脑内和大脑间结构连接的大规模缺陷，同时也强调了哪些通路对正常的音乐感知至关重要。
