[炎症性与非炎症性局部晚期乳腺癌的对比研究——一家摩洛哥医院的经验]

[Comparative study of inflammatory and non-inflammatory locally advanced breast cancer - the experience of a Moroccan hospital].

作者信息

Benbrahim Z, Berrada A, Amaadour L, Zahra El M'rabet F, Elfatemi H, Elfakir S, Mellas N, Arifi S

机构信息

Service d'oncologie médicale, faculté de médecine et de pharmacie de Fès, université Sidi Mohammed Ben Abdellah, CHU Hassan II de Fès, route sidi Hrazem, Fès, Maroc.

出版信息

Gynecol Obstet Fertil Senol. 2017 Nov;45(11):604-608. doi: 10.1016/j.gofs.2017.09.005.

DOI:10.1016/j.gofs.2017.09.005

PMID:29100820

Abstract

OBJECTIVES

The locally advanced breast cancer (LABC) covers large tumor heterogeneity. It consists of non-inflammatory LABC and inflammatory breast cancer (IBC). This study aimed to compare the epidemiological, clinical and pathological, as well as the prognosis of IBC versus non-inflammatory LABC.

METHODS

This is a retrospective study of 150 cases of IBC and non-inflammatory LABC collected in medical oncology department of the CHU Hassan II of Fez during a period of 4 years [January 2009-January 2013]. Overall survival (OS) and disease-free survival (DFS) were calculated using the Kaplan-Meier method. Analysis of the various prognostic factors was performed according to the Cox model.

RESULTS

IBC represented 28.7% of LABC. The median age was 47 years. The median tumor size was greater in non-inflammatory LABC compared with IBC (9.5 versus 6cm; P=0.0014). Lymph node invasion was more common in the IBC (49.7% versus 45.9%; P=0.01). An SBR grade 3 was more frequently noted in the IBC (P=0.011). The two groups were well balanced with regard to HR, HER2 status and pathologic complete response. Non-inflammatory LABC had the best OS and DFS (24 vs. 22 months; P=0.03 and 18 vs. 17 months; P=0.025 respectively).

CONCLUSION

IBC has a worse prognosis compared to non-inflammatory LABC. New therapeutic approaches are needed to improve the prognosis of these patients.

摘要

目的

局部晚期乳腺癌（LABC）存在较大的肿瘤异质性。它包括非炎性LABC和炎性乳腺癌（IBC）。本研究旨在比较IBC与非炎性LABC的流行病学、临床病理特征以及预后。

方法

这是一项回顾性研究，收集了非斯哈桑二世大学医院肿瘤内科在4年期间（2009年1月至2013年1月）的150例IBC和非炎性LABC病例。采用Kaplan-Meier法计算总生存期（OS）和无病生存期（DFS）。根据Cox模型对各种预后因素进行分析。

结果

IBC占LABC的28.7%。中位年龄为47岁。非炎性LABC的中位肿瘤大小大于IBC（9.5对6cm；P=0.0014）。IBC中淋巴结侵犯更常见（49.7%对45.9%；P=0.01）。IBC中更常出现SBR 3级（P=0.011）。两组在HR、HER2状态和病理完全缓解方面均衡良好。非炎性LABC的OS和DFS最佳（分别为24个月对22个月；P=0.03和18个月对17个月；P=0.025）。