Aller Maria-Angeles, Arias Jose-Ignacio, Arias Jaime
Surgery I Department, School of Medicine, Complutense University of Madrid, Madrid, Spain.
Theor Biol Med Model. 2010 Sep 14;7:37. doi: 10.1186/1742-4682-7-37.
Post-traumatic inflammation is formed by molecular and cellular complex mechanisms whose final goal seems to be injured tissue regeneration.In the skin -an exterior organ of the body- mechanical or thermal injury induces the expression of different inflammatory phenotypes that resemble similar phenotypes expressed during embryo development. Particularly, molecular and cellular mechanisms involved in gastrulation return. This is a developmental phase that delineates the three embryonic germ layers: ectoderm, endoderm and mesoderm. Consequently, in the post-natal wounded skin, primitive functions related with the embryonic mesoderm, i.e. amniotic and yolk sac-derived, are expressed. Neurogenesis and hematogenesis stand out among the primitive function mechanisms involved.Interestingly, in these phases of the inflammatory response, whose molecular and cellular mechanisms are considered as traces of the early phases of the embryonic development, the mast cell, a cell that is supposedly inflammatory, plays a key role.The correlation that can be established between the embryonic and the inflammatory events suggests that the results obtained from the research regarding both great fields of knowledge must be interchangeable to obtain the maximum advantage.
创伤后炎症是由分子和细胞的复杂机制形成的，其最终目标似乎是受损组织的再生。在皮肤——身体的一个外部器官——机械或热损伤会诱导不同炎症表型的表达，这些表型类似于胚胎发育过程中表达的类似表型。特别是，涉及原肠胚形成的分子和细胞机制会重现。这是一个划分三个胚胎胚层（外胚层、内胚层和中胚层）的发育阶段。因此，在出生后受伤的皮肤中，与胚胎中胚层相关的原始功能，即羊膜和卵黄囊衍生的功能会被表达。神经发生和造血作用在涉及的原始功能机制中较为突出。有趣的是，在这些炎症反应阶段，其分子和细胞机制被认为是胚胎发育早期阶段的痕迹，肥大细胞，一种被认为具有炎症性的细胞，发挥着关键作用。胚胎事件与炎症事件之间可以建立的相关性表明，从这两个重要知识领域的研究中获得的结果必须是可互换的，以获得最大优势。 。
