光诱导对眼晶状体阳离子泵的损伤：维生素C的预防作用。
Light-induced damage to ocular lens cation pump: prevention by vitamin C.
作者信息
Varma S D, Kumar S, Richards R D
出版信息
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3504-6. doi: 10.1073/pnas.76.7.3504.
Abstract
The cation pump activity of the ocular lens was damaged by exposure to light in the presence of riboflavin phosphate. The intensity of light was similar to that used for reading purposes. The observed light-induced damage was due to superoxide or its derivatives, the superoxide being produced photochemically. Such damage was attenuated by vitamin C in amounts comparable to that in the aqueous humor. Thus, a new role for the high ascorbate level present in the anterior chamber fluid and the lens has been suggested. Ascorbate in other tissues also might have this novel physiological function of protecting against damage due to superoxide and its derivatives produced during normal cellular oxidation.
摘要
在磷酸核黄素存在的情况下，暴露于光线下会损害眼晶状体的阳离子泵活性。光照强度与阅读时所用的强度相似。观察到的光诱导损伤是由于超氧化物或其衍生物造成的，超氧化物是通过光化学产生的。这种损伤可被与房水中含量相当的维生素C减轻。因此，有人提出前房液和晶状体中高含量的抗坏血酸盐具有新的作用。其他组织中的抗坏血酸盐也可能具有这种新的生理功能，即保护细胞免受正常细胞氧化过程中产生的超氧化物及其衍生物的损伤。
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