脓毒症和应激状态下的血浆氨基酸谱
Plasma-amino acid profiles in sepsis and stress.
作者信息
Vente J P, von Meyenfeldt M F, van Eijk H M, van Berlo C L, Gouma D J, van der Linden C J, Soeters P B
机构信息
Department of Surgery, Maastricht University Hospital, The Netherlands.
出版信息
Ann Surg. 1989 Jan;209(1):57-62. doi: 10.1097/00000658-198901000-00009.
Sepsis has been associated with specific plasma amino acid patterns. Sixty-five patients were prospectively investigated as to whether these patterns are indeed sepsis specific, or specific for metabolic stress without concomitant sepsis, or associated with the presence of organ failure. Virtually all aminoacid levels were decreased by 10-30% (p less than 0.05), whereas cystine and phenylalanine were significantly elevated. These changes were more pronounced in severe sepsis. Organ failure was not associated with significantly altered amino acid profiles. No differences were found between sepsis and stress without signs of sepsis. In addition, imminent death was not associated with aberrant amino acid profiles. We conclude that sepsis and metabolic stress are associated with changes in plasma amino acid profiles, but that such changes are aspecific and therefore poor indicators of disease severity.
脓毒症与特定的血浆氨基酸模式有关。对65名患者进行了前瞻性研究，以确定这些模式是否确实是脓毒症特有的，还是代谢应激（无并发脓毒症）特有的，或者与器官衰竭的存在有关。几乎所有氨基酸水平均下降了10%-30%（p<0.05），而胱氨酸和苯丙氨酸显著升高。这些变化在严重脓毒症中更为明显。器官衰竭与氨基酸谱的显著改变无关。脓毒症与无脓毒症迹象的应激之间未发现差异。此外，濒死与异常的氨基酸谱无关。我们得出结论，脓毒症和代谢应激与血浆氨基酸谱的变化有关，但这些变化是非特异性的，因此不是疾病严重程度的良好指标。
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