State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Resources Utilization and Protection, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Resources Utilization and Protection, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, People's Republic of China.
Sci Total Environ. 2018 Mar;616-617:1339-1346. doi: 10.1016/j.scitotenv.2017.10.183. Epub 2017 Nov 6.
Common carps (Cyprinus carpio) were exposed to syn- and anti-Dechlorane Plus (DP) isomers to investigate absorption, tissue distribution, and stereoselective bioaccumulation of DP isomers. The absorption efficiencies of anti-DP in the gastrointestinal system were higher than those of syn-DP. A linear accumulation was found for both isomers in all fish tissues except for serum; and the liver and gill exhibited the highest and lowest DP assimilation efficiency, respectively. The elimination of DP isomers in all tissues followed first-order kinetics, with the fastest depuration rate occurring in the liver and serum. The biomagnification factors (BMFs) of both isomers were less than one in all tissues, except for serum. Anti-DP was preferably accumulated in the liver, gill, and serum, whereas syn-DP was selectively accumulated in the carcass and gastrointestinal tract. As a whole, fish did not show selective accumulation of the syn- or anti-DP isomer in the uptake stage, whereas a selective accumulation of syn-DP in fish was observed during the depuration period, which could be due to a selective excretion of anti-DP. Metabolism cannot be ruled out as a possible reason considering the high f values and the high elimination rate of DPs in the liver.
鲤鱼（Cyprinus carpio）暴露于反式和顺式十氯酮（DP）异构体中，以研究 DP 异构体的吸收、组织分布和立体选择性生物累积。反式 DP 在胃肠道中的吸收效率高于顺式 DP。除血清外，所有鱼类组织中均发现两种异构体呈线性累积；肝脏和鳃分别表现出最高和最低的 DP 同化效率。两种异构体在所有组织中的消除均遵循一级动力学，肝脏和血清中的清除率最快。除血清外，两种异构体在所有组织中的生物放大因子（BMFs）均小于 1。反式 DP 优先在肝脏、鳃和血清中累积，而顺式 DP 则选择性地在胴体和胃肠道中累积。总的来说，鱼类在摄取阶段并没有表现出对顺式或反式 DP 异构体的选择性累积，而在清除阶段观察到顺式 DP 的选择性累积，这可能是由于反式 DP 的选择性排泄。考虑到肝脏中 DP 的 f 值较高和消除率较高，不能排除代谢是一种可能的原因。
