Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Divisions of Medical Oncology and Dermatology, Department of Medicine, University of Washington, Seattle, Washington.
Divisions of Medical Oncology and Dermatology, Department of Medicine, University of Washington, Seattle, Washington.
J Am Acad Dermatol. 2018 Mar;78(3):457-463.e2. doi: 10.1016/j.jaad.2017.10.028. Epub 2017 Nov 2.
Merkel cell carcinoma (MCC) incidence rates are rising and strongly age-associated, relevant for an aging population.
Determine MCC incidence in the United States and project incident cases through the year 2025.
Registry data were obtained from the SEER-18 Database, containing 6600 MCC cases. Age- and sex-adjusted projections were generated using US census data.
During 2000-2013, the number of reported solid cancer cases increased 15%, melanoma cases increased 57%, and MCC cases increased 95%. In 2013, the MCC incidence rate was 0.7 cases/100,000 person-years in the United States, corresponding to 2488 cases/year. MCC incidence increased exponentially with age, from 0.1 to 1.0 to 9.8 (per 100,000 person-years) among age groups 40-44 years, 60-64 years, and ≥85 years, respectively. Due to aging of the Baby Boomer generation, US MCC incident cases are predicted to climb to 2835 cases/year in 2020 and 3284 cases/year in 2025.
We assumed that the age-adjusted incidence rate would stabilize, and thus, the number of incident cases we projected might be an underestimate.
An aging population is driving brisk increases in the number of new MCC cases in the United States. This growing impact combined with the rapidly evolving therapeutic landscape warrants expanded awareness of MCC diagnosis and management.
默克尔细胞癌（MCC）的发病率正在上升，且与年龄高度相关，这与人口老龄化有关。
确定美国的 MCC 发病率，并预测 2025 年的发病病例数。
从包含 6600 例 MCC 病例的 SEER-18 数据库中获取登记数据。使用美国人口普查数据生成年龄和性别调整后的预测值。
2000-2013 年间，报告的实体瘤病例数增加了 15%，黑色素瘤病例数增加了 57%，而 MCC 病例数增加了 95%。2013 年，美国 MCC 的发病率为 0.7 例/10 万人年，相当于每年 2488 例。MCC 发病率随年龄呈指数增长，在 40-44 岁、60-64 岁和≥85 岁的年龄组中，发病率分别为 0.1、1.0 和 9.8（每 10 万人年）。由于婴儿潮一代的老龄化，预计美国 MCC 的发病病例数将在 2020 年上升至 2835 例/年，在 2025 年上升至 3284 例/年。
我们假设年龄调整后的发病率将稳定，因此，我们预测的发病病例数可能低估了实际情况。
人口老龄化正在推动美国新 MCC 病例数的快速增长。这种日益增长的影响，加上迅速发展的治疗领域，需要提高对 MCC 诊断和管理的认识。
