Royal North Shore Hospital, Sydney, NSW, Australia.
Northern Clinical School, University of Sydney, Sydney, NSW, Australia.
Australas J Dermatol. 2020 Feb;61(1):e34-e38. doi: 10.1111/ajd.13131. Epub 2019 Aug 19.
BACKGROUND/OBJECTIVES: Merkel cell carcinoma (MCC) is a highly invasive cutaneous malignancy. The objective of this study was to investigate the incidence and trends of MCC in Victoria, Australia, between 1986 and 2016.
Population-based, descriptive analysis of Victorian Cancer Registry (VCR) data. The de-identified records of patients with MCC were obtained from Victoria residents diagnosed between 1986 and 2016. Trends in age-standardised incidences were examined using joinpoint analysis.
A total of 1095 cases were found. Incidence of MCC was 3.9 per 100 000 for men and 1.5 per 100 000 for women. The incidence of MCC in men 66-85 is increasing at an annual rate of 4.2% (2.8-5.8%, 95% CI). However, since 2002 the incidence in women in the same age group has been decreasing. Whilst there is an overall stabilisation in the incidence of MCC, incidence of MCC for males is increasing. For MCC in males 85 years old and over, the incidence of MCC was 26.8 per 100 000 between 2012 and 2016. Relative 5-year survival for patients diagnosed between 2008 and 2012 is 50%.
Merkel cell carcinoma remains an aggressive cancer, especially among older men. Differences in trends seen in local data can help target preventative and early intervention management strategies in specific groups.
背景/目的：默克尔细胞癌（MCC）是一种高度侵袭性的皮肤恶性肿瘤。本研究的目的是调查 1986 年至 2016 年间澳大利亚维多利亚州 MCC 的发病率和趋势。
对维多利亚癌症登记处（VCR）数据进行基于人群的描述性分析。从维多利亚州居民中获得了 1986 年至 2016 年间诊断为 MCC 的患者的匿名记录。使用 joinpoint 分析检查年龄标准化发病率的趋势。
共发现 1095 例病例。男性 MCC 的发病率为 3.9/100000，女性为 1.5/100000。66-85 岁男性 MCC 的发病率以每年 4.2%的速度增长（2.8-5.8%，95%CI）。然而，自 2002 年以来，同一年龄组女性的发病率一直在下降。尽管 MCC 的发病率总体上趋于稳定，但男性 MCC 的发病率仍在上升。2012 年至 2016 年期间，85 岁及以上男性 MCC 的发病率为 26.8/100000。2008 年至 2012 年期间诊断的患者的 5 年相对生存率为 50%。
默克尔细胞癌仍然是一种侵袭性癌症，尤其是在老年男性中。当地数据中观察到的趋势差异有助于针对特定人群制定预防和早期干预管理策略。
