Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, USA; Murdoch Childrens Research Institute, Melbourne, Australia.
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, USA.
Neuroscience. 2017 Dec 26;367:211-218. doi: 10.1016/j.neuroscience.2017.10.039. Epub 2017 Nov 2.
Speech sound disorder (SSD) is common, yet its neurobiology is poorly understood. Recent studies indicate atypical structural and functional anomalies either in one hemisphere or both hemispheres, which might be accompanied by alterations in inter-hemispheric connectivity. Indeed, abnormalities of the corpus callosum - the main fiber tract connecting the two hemispheres - have been linked to speech and language deficits in associated disorders, such as stuttering, dyslexia, aphasia, etc. However, there is a dearth of studies examining the corpus callosum in SSD. Here, we investigated whether a sample of 18 children with SSD differed in callosal morphology from 18 typically developing children carefully matched for age. Significantly reduced dimensions of the corpus callosum, particularly in the callosal anterior third, were observed in children with SSD. These findings indicating pronounced callosal aberrations in SSD make an important contribution to an understudied field of research and may suggest that SSD is accompanied by atypical lateralization of speech and language function.
言语障碍(SSD)很常见,但它的神经生物学机制还不太清楚。最近的研究表明,无论是在一个半球还是两个半球,都存在异常的结构和功能异常,这可能伴随着半球间连接的改变。事实上,胼胝体——连接两个半球的主要纤维束——的异常与口吃、阅读障碍、失语症等相关疾病的言语和语言缺陷有关。然而,目前还缺乏研究 SSD 中胼胝体的研究。在这里,我们研究了 18 名 SSD 儿童的样本是否在胼胝体形态上与 18 名年龄匹配的典型发育儿童存在差异。我们观察到 SSD 儿童的胼胝体尺寸显著减小,特别是在前三分之一处。这些发现表明 SSD 中存在明显的胼胝体异常,这对一个研究不足的领域做出了重要贡献,可能表明 SSD 伴随着言语和语言功能的非典型侧化。