Hagman M, Jagenburg R
Department of Clinical Chemistry, Gothenburg University, Sahlgren's Hospital, Sweden.
Biochem Pharmacol. 1989 Jan 1;38(1):105-8. doi: 10.1016/0006-2952(89)90156-1.
It has been shown earlier that an acute dose of ethanol causes an immediate decrease in the concentration of most plasma amino acids, and that this decrease involves both beta-adrenergic and adrenocortical mechanisms. In this work is shown that the oxidation of ethanol also plays an important role in the amino acid decreasing effect. Male rats were pretreated with 4-methylpyrazole, an inhibitor of liver alcohol dehydrogenase, in doses causing an 85% inhibition of the ethanol elimination. In this group the ethanol-induced decrease in amino acids was much less pronounced than in a control group pretreated with saline.
早期研究表明，急性剂量的乙醇会使大多数血浆氨基酸浓度立即降低，且这种降低涉及β-肾上腺素能和肾上腺皮质机制。本研究表明，乙醇的氧化在氨基酸降低效应中也起重要作用。给雄性大鼠预先注射4-甲基吡唑（一种肝醇脱氢酶抑制剂），剂量能抑制乙醇消除达85%。与用生理盐水预处理的对照组相比，该组中乙醇诱导的氨基酸降低不太明显。
