Hagman M, Eriksson T
Department of Clinical Chemistry, Sahlgren's Hospital, University of Gothenburg, Sweden.
J Pharm Pharmacol. 1990 Dec;42(12):869-70. doi: 10.1111/j.2042-7158.1990.tb07043.x.
Male rats were given three different doses of ethanol in i.p. injections (0.66, 1.33 and 2.00 g kg-1). A dose-dependent decrease in the concentrations of most plasma amino acids was observed. For the total amino acid concentration this decrease was 5, 16 and 22%, respectively, compared with a saline-treated control group. It has previously been suggested that the oxidation of ethanol plays an important role in the amino acid decreasing effect of ethanol. In this study the lowest dose used (0.66 g kg-1) was calculated to be high enough to keep the enzyme systems involved in ethanol oxidation saturated during the 60 min course of the experiment. The observation that the ethanol-induced decrease in plasma amino acid levels was more pronounced with higher ethanol doses indicates that not only the oxidation of ethanol but also ethanol itself is important in the effect of ethanol on plasma amino acid concentrations.
给雄性大鼠腹腔注射三种不同剂量的乙醇（0.66、1.33和2.00 g kg-1）。观察到大多数血浆氨基酸浓度呈剂量依赖性下降。与生理盐水处理的对照组相比，总氨基酸浓度的下降分别为5%、16%和22%。此前有研究表明，乙醇的氧化在乙醇降低氨基酸的作用中起重要作用。在本研究中，所用的最低剂量（0.66 g kg-1）经计算足以使参与乙醇氧化的酶系统在60分钟的实验过程中保持饱和状态。乙醇剂量越高，乙醇诱导的血浆氨基酸水平下降越明显，这一观察结果表明，不仅乙醇的氧化，而且乙醇本身对乙醇影响血浆氨基酸浓度都很重要。
