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An adenovirus type 5 early gene function regulates expression of other early viral genes.

作者信息

Jones N, Shenk T

出版信息

Proc Natl Acad Sci U S A. 1979 Aug;76(8):3665-9. doi: 10.1073/pnas.76.8.3665.

DOI:10.1073/pnas.76.8.3665
PMID:291030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC383893/
Abstract

We have identified an adenovirus type 5(Ad5) early gene function located in early region 1 which is required for the production of early cytoplasmic mRNAs corresponding to early regions 2, 3, and 4. Mutant dl312 (lacks the segment between 1.5 and 4.5 map units) grows as well as wild-type virus in 293 cells (Ad5-transformed human embryonic kidney cells), but its growth is severely restricted in HeLa cells. We detect no viral RNAs in the cytoplasm of dl312-infected HeLa cells. Viral RNA sequences are present, however, in dl312-infected HeLa cell nuclei.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8f/383893/67eb4ce07136/pnas00008-0105-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8f/383893/c104be47bc8a/pnas00008-0103-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8f/383893/67eb4ce07136/pnas00008-0105-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8f/383893/c104be47bc8a/pnas00008-0103-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa8f/383893/67eb4ce07136/pnas00008-0105-a.jpg

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An adenovirus type 5 early gene function regulates expression of other early viral genes.
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本文引用的文献

1
RNA of low molecular weight in KB cells infected with adenovirus type 2.感染2型腺病毒的KB细胞中的低分子量RNA
J Mol Biol. 1966 Jun;17(2):428-39. doi: 10.1016/s0022-2836(66)80153-5.
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Effect of cycloheximide on RNA metabolism early in productive infection with adenovirus 2.放线菌酮对腺病毒2 productive感染早期RNA代谢的影响
J Virol. 1974 Jul;14(1):26-32. doi: 10.1128/JVI.14.1.26-32.1974.
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Role of DNA-dependent RNA polymerases II and III in transcription of the adenovirus genome late in productive infection.DNA依赖性RNA聚合酶II和III在腺病毒基因组生产性感染后期转录中的作用。
腺病毒载体在基因治疗和疫苗方法中的应用。
Genet Mol Biol. 2022 Oct 7;45(3 Suppl 1):e20220079. doi: 10.1590/1678-4685-GMB-2022-0079. eCollection 2022.
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Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies.新兴的抗人类腺病毒感染治疗药物：最新进展和新策略。
Antiviral Res. 2021 Apr;188:105034. doi: 10.1016/j.antiviral.2021.105034. Epub 2021 Feb 10.
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Differential Splicing of Human Adenovirus 5 E1A RNA Expressed in versus in .人腺病毒 5 E1A RNA 在 中与 在 中表达的差异剪接。
J Virol. 2021 Feb 24;95(6). doi: 10.1128/JVI.02081-20.
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Multiple domains in the 50 kDa form of E4F1 regulate promoter-specific repression and E1A trans-activation.E4F1的50千道尔顿形式中的多个结构域调节启动子特异性抑制和E1A反式激活。
Gene. 2020 Sep 5;754:144882. doi: 10.1016/j.gene.2020.144882. Epub 2020 Jun 11.
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Nat Commun. 2020 Apr 24;11(1):1997. doi: 10.1038/s41467-020-15844-2.
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Genetic analysis of simian virus 40. 3. Characterization of a temperature-sensitive mutant blocked at an early stage of productive infection in monkey cells.猴病毒40的遗传分析。3. 一种在猴细胞生产性感染早期受阻的温度敏感突变体的特性。
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10
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Cold Spring Harb Symp Quant Biol. 1975;39 Pt 1:419-26. doi: 10.1101/sqb.1974.039.01.054.