Goto S, Ogata K, Fujie T, Fujigaki T, Nakamura H, Yukinari T, Shibata O
Department of Anesthesiology, Nagasaki University School of Medicine.
Masui. 1993 Feb;42(2):271-5.
Caesarean section in a 26 year old patient (50 kg, normal weight 36 kg) with past history of fulminant malignant hyperthermia (f-MH) is reported. Hyperthermia over 42 degrees C and subsequent cardiac arrest occurred during general anesthesia with nitrous oxide-oxygen-halothane and succinylcholine when she had been planned to perform hip joint arthroplasty at the age of 7. Prophylactic oral dantrolene administration started 4 days before the operation and the dose went up to 75 mg. Further 25 mg was given as premedication on the day of the operation. Intravenous dantrolene was administered 1.2 mg.kg-1 during the operation and 0.6 mg.kg-1 on the day after surgery. The Caesarean section was performed under spinal anesthesia with hyperbaric tetracaine 20 mg. No clinical symptoms of MH occurred during perioperative period. The delivered baby was a healthy female and no side effects of dantrolene were observed.
报道了一名26岁患者（体重50kg，正常体重36kg）行剖宫产手术的病例，该患者既往有暴发性恶性高热（f-MH）病史。患者7岁时计划行髋关节置换术，在氧化亚氮-氧气-氟烷和琥珀酰胆碱全身麻醉期间，体温超过42℃，随后发生心脏骤停。术前4天开始预防性口服丹曲林，剂量增至75mg。手术当天术前再给予25mg。术中静脉注射丹曲林1.2mg·kg-1，术后当天给予0.6mg·kg-1。剖宫产手术在腰麻下进行，使用20mg重比重丁卡因。围手术期未出现恶性高热的临床症状。分娩的婴儿为健康女婴，未观察到丹曲林的副作用。
