School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
Carbohydr Polym. 2018 Jan 15;180:104-111. doi: 10.1016/j.carbpol.2017.10.031. Epub 2017 Oct 7.
A major challenge in bone tissue engineering is the development of biomimetic scaffolds which should simultaneously meet mechanical strength and pore structure requirements. Herein, we combined technologies of high concentration solvent casting, particulate leaching, and room temperature compression molding to prepare a novel poly(lactic acid)/ethyl cellulose/hydroxyapatite (PLA/EC/HA) scaffold. The functional, structural and mechanical properties of the obtained porous scaffolds were characterized. The results indicated that the PLA/EC/HA scaffolds at the 20wt% HA loading level showed optimal mechanical properties and desired porous structure. Its porosity, contact angle, compressive yield strength and weight loss after 56days were 84.28±7.04%, 45.13±2.40°, 1.57±0.09MPa and 4.77±0.32%, respectively, which could satisfy the physiological demands to guide bone regeneration. Thus, the developed scaffolds have potential to be used as a bone substitute material for bone tissue engineering application.
在骨组织工程中，一个主要的挑战是开发仿生支架，该支架应同时满足机械强度和孔结构要求。在此，我们结合高浓度溶剂浇铸、颗粒溶出和室温压缩成型技术，制备了一种新型聚乳酸/乙基纤维素/羟基磷灰石（PLA/EC/HA）支架。对所得多孔支架的功能、结构和机械性能进行了表征。结果表明，在 20wt%HA 负载水平下，PLA/EC/HA 支架表现出最佳的机械性能和理想的多孔结构。其孔隙率、接触角、压缩屈服强度和 56 天后的失重率分别为 84.28±7.04%、45.13±2.40°、1.57±0.09MPa 和 4.77±0.32%，这些性能可以满足引导骨再生的生理需求。因此，所开发的支架具有作为骨组织工程应用的骨替代材料的潜力。
