《行动呼吁：寻找隐球菌疫苗》
A Call to Arms: Quest for a Cryptococcal Vaccine.
机构信息
Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USA; The South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, USA.
Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USA; The South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, USA.
出版信息
Trends Microbiol. 2018 May;26(5):436-446. doi: 10.1016/j.tim.2017.10.002. Epub 2017 Nov 2.
Abstract
Cryptococcosis remains a significant cause of morbidity and mortality world-wide, particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically available to treat or prevent cryptococcosis. In this review, we provide a rationale to support continued investment in Cryptococcus vaccine research, potential challenges that must be overcome along the way, and a literature review of the current progress underway towards developing a vaccine to prevent cryptococcosis.
摘要
隐球菌病仍然是全球范围内发病率和死亡率的重要原因，特别是在艾滋病患者中。然而，迄今为止，临床上还没有许可的疫苗可用于治疗或预防隐球菌病。在这篇综述中，我们提供了一个支持继续投资隐球菌疫苗研究的理由，讨论了在开发预防隐球菌病疫苗的过程中必须克服的潜在挑战，并回顾了目前正在进行的相关研究进展。
相似文献
1
A Call to Arms: Quest for a Cryptococcal Vaccine.
Trends Microbiol. 2018 May;26(5):436-446. doi: 10.1016/j.tim.2017.10.002. Epub 2017 Nov 2.
2
Vaccination with Recombinant Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species.
mBio. 2017 Nov 28;8(6):e01872-17. doi: 10.1128/mBio.01872-17.
3
Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts.
mBio. 2015 Dec 22;6(6):e01905-15. doi: 10.1128/mBio.01905-15.
4
A Heat-Killed Mutant Strain Induces Host Protection against Multiple Invasive Mycoses in a Murine Vaccine Model.
mBio. 2019 Nov 26;10(6):e02145-19. doi: 10.1128/mBio.02145-19.
5
Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants.
mBio. 2015 Oct 6;6(5):e01433-15. doi: 10.1128/mBio.01433-15.
6
Feasibility and prospects for a vaccine to prevent cryptococcosis.
Med Mycol. 2005 Dec;43(8):667-80. doi: 10.1080/13693780500448230.
7
Protection of mice against experimental cryptococcosis using glucan particle-based vaccines containing novel recombinant antigens.
Vaccine. 2020 Jan 16;38(3):620-626. doi: 10.1016/j.vaccine.2019.10.051. Epub 2019 Nov 4.
8
Methodology for Anti-Cryptococcal Vaccine Development.
Methods Mol Biol. 2017;1625:129-140. doi: 10.1007/978-1-4939-7104-6_10.
9
Vaccine Strategies for Cryptococcus neoformans.
Methods Mol Biol. 2024;2775:411-422. doi: 10.1007/978-1-0716-3722-7_28.
10
Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model.
mBio. 2019 Apr 2;10(2):e02909-18. doi: 10.1128/mBio.02909-18.
引用本文的文献
1
infections: aspartyl protease potential to improve outcome in susceptible hosts.
mBio. 2024 Nov 13;15(11):e0273324. doi: 10.1128/mbio.02733-24. Epub 2024 Oct 23.
2
Advances in Dendritic-Cell-Based Vaccines against Respiratory Fungal Infections.
Vaccines (Basel). 2024 Aug 28;12(9):981. doi: 10.3390/vaccines12090981.
3
Inhibition of host 5-lipoxygenase reduces overexuberant inflammatory responses and mortality associated with meningoencephalitis.
mBio. 2024 Sep 11;15(9):e0148324. doi: 10.1128/mbio.01483-24. Epub 2024 Jul 31.
4
Adjuvant ArtinM favored the host immunity against infection in C57BL/6 mice.
Immunotherapy. 2024;16(11):733-748. doi: 10.1080/1750743X.2024.2360384. Epub 2024 Jun 28.
5
Fungal vaccines and adjuvants: a tool to reveal the interaction between host and fungi.
Arch Microbiol. 2024 Jun 8;206(7):293. doi: 10.1007/s00203-024-04010-7.
6
Semisynthetic Glycoconjugate Vaccine Candidates against .
ACS Infect Dis. 2024 Jun 14;10(6):2089-2100. doi: 10.1021/acsinfecdis.4c00094. Epub 2024 May 31.
7
Chitosan-Deficient Cryptococcus as Whole-Cell Vaccines.
Methods Mol Biol. 2024;2775:393-410. doi: 10.1007/978-1-0716-3722-7_27.
8
Semi-synthetic glycoconjugate vaccine candidate against .
bioRxiv. 2024 Feb 3:2024.02.02.578725. doi: 10.1101/2024.02.02.578725.
9
A consensus structural motif for the capsular polysaccharide of by NMR/MD.
Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2322413121. doi: 10.1073/pnas.2322413121. Epub 2024 Feb 9.
10
Dendritic Cells: Multifunctional Roles in Host Defenses to Infections.
J Fungi (Basel). 2023 Oct 26;9(11):1050. doi: 10.3390/jof9111050.
本文引用的文献
1
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.
Lancet Infect Dis. 2017 Aug;17(8):873-881. doi: 10.1016/S1473-3099(17)30243-8. Epub 2017 May 5.
2
Evaluation of trained immunity by β-1, 3 (d)-glucan on murine monocytes in vitro and duration of response in vivo.
Immunol Cell Biol. 2017 Aug;95(7):601-610. doi: 10.1038/icb.2017.13. Epub 2017 Feb 23.
3
Is a Primary Pathogen?
J Fungi (Basel). 2015;1(2):154-167. doi: 10.3390/jof1020154. Epub 2015 Jul 29.
4
Induction of Protective Immunity to Cryptococcal Infection in Mice by a Heat-Killed, Chitosan-Deficient Strain of Cryptococcus neoformans.
mBio. 2016 May 10;7(3):e00547-16. doi: 10.1128/mBio.00547-16.
5
Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis.
PLoS One. 2016 Apr 15;11(4):e0153853. doi: 10.1371/journal.pone.0153853. eCollection 2016.
6
Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts.
mBio. 2015 Dec 22;6(6):e01905-15. doi: 10.1128/mBio.01905-15.
7
Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants.
mBio. 2015 Oct 6;6(5):e01433-15. doi: 10.1128/mBio.01433-15.
8
The Cnes2 locus on mouse chromosome 17 regulates host defense against cryptococcal infection through pleiotropic effects on host immunity.
Infect Immun. 2015 Dec;83(12):4541-54. doi: 10.1128/IAI.00697-15. Epub 2015 Sep 14.
9
Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var. grubii strain H99 and Cryptococcus gattii strain R265.
Microbes Infect. 2016 Jan;18(1):57-67. doi: 10.1016/j.micinf.2015.08.017. Epub 2015 Sep 11.
10
STAT1 signaling within macrophages is required for antifungal activity against Cryptococcus neoformans.
Infect Immun. 2015 Dec;83(12):4513-27. doi: 10.1128/IAI.00935-15. Epub 2015 Sep 8.
Zotero 插件