Casadevall Arturo, Pirofski Liise-Anne
Division of Infectious Diseases of the Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Med Mycol. 2005 Dec;43(8):667-80. doi: 10.1080/13693780500448230.
Cryptococcosis is a relatively common fungal disease caused by Cryptococcus neoformans that has high morbidity and mortality. Numerous studies have established the feasibility of enhancing host immunity to C neoformans in naive immunocompetent animal models by vaccination. Several antigens have been identified that appear to be suitable vaccine candidates. Induced immune responses can mediate protection through both humoral and cellular immunity. Hence, a vaccine against cryptococcosis in humans is probably feasible but there are significant obstacles to vaccine development that range from uncertainties about the pathogenesis of infection to economic considerations.
隐球菌病是一种相对常见的真菌病，由新型隐球菌引起，具有较高的发病率和死亡率。众多研究已证实，在未感染的免疫健全动物模型中，通过接种疫苗增强宿主对新型隐球菌的免疫力是可行的。已鉴定出几种似乎适合作为疫苗候选物的抗原。诱导的免疫反应可通过体液免疫和细胞免疫介导保护作用。因此，开发针对人类隐球菌病的疫苗可能是可行的，但疫苗研发存在重大障碍，从感染发病机制的不确定性到经济因素等不一而足。
