Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou 215006, Jiangsu, China; Department of Endocrinology and Metabolism, Xinghua People's Hospital, 419 Yingwu Road, Xinghua 225700, Jiangsu, China.
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou 215006, Jiangsu, China.
Clin Chim Acta. 2019 Feb;489:183-188. doi: 10.1016/j.cca.2017.10.034. Epub 2017 Nov 3.
Asprosin has been identified as a novel hormone enriched in white adipose tissue and is pathologically increased in insulin-resistant mice and humans. However, information regarding the role of asprosin in type 2 diabetes mellitus (T2DM) remains unavailable. Via conducting a hospital-based study, we purposed to ascertain the potential relationship between circulating asprosin concentrations and T2DM.
The study recruited 84 adults with T2DM and 86 controls with normal glucose tolerance. They matched in age, body mass index (BMI), and sex. Serum asprosin concentrations were measured via ELISA method.
Compared to the controls, serum asprosin concentrations were significantly increased in the T2DM adults (P<0.001). As asprosin concentrations increased across its tertiles, the percentage of T2DM increased (39.28, 37.50, and 70.68%; P value for trend <0.001). Multivariate logistic regression models demonstrated that compared with the 1st tertile of asprosin, the odds ratio of T2DM was 3.278(95% CI 1.053-10.200, P=0.040) for the 3rd tertile after adjustment for potential confounders. Area under ROC curve of asprosin (sex and age adjusted) for predicting the presence of T2DM was 0.707[95% CI 0.628-0.786]. Finally, multiple stepwise regression analysis indicated that fasting glucose and triglyceride were independently associated with serum asprosin in T2DM.
Asprosin concentrations are increased in adults with T2DM. The results suggest that asprosin might serve as a risk factor associated with the pathogenesis of T2DM, but not an ideal biomarker for predicting T2DM.
内脂素作为一种新型激素，在白色脂肪组织中含量丰富，在胰岛素抵抗的小鼠和人类中病理性增加。然而，关于内脂素在 2 型糖尿病（T2DM）中的作用的信息仍然未知。通过进行一项基于医院的研究，我们旨在确定循环内脂素浓度与 T2DM 之间的潜在关系。
该研究招募了 84 名 T2DM 成人和 86 名糖耐量正常的对照者。他们在年龄、体重指数（BMI）和性别方面相匹配。通过 ELISA 法测量血清内脂素浓度。
与对照组相比，T2DM 成人的血清内脂素浓度显著升高（P<0.001）。随着内脂素浓度在其三等分位范围内升高，T2DM 的比例也随之增加（39.28%、37.50%和 70.68%；趋势 P 值<0.001）。多变量逻辑回归模型表明，与内脂素第 1 三分位相比，第 3 三分位的 T2DM 比值比为 3.278（95%CI 1.053-10.200，P=0.040），校正潜在混杂因素后。内脂素（性别和年龄校正）预测 T2DM 存在的 ROC 曲线下面积为 0.707[95%CI 0.628-0.786]。最后，多元逐步回归分析表明，空腹血糖和甘油三酯与 T2DM 患者的血清内脂素有独立相关性。
T2DM 成人的内脂素浓度升高。结果表明，内脂素可能作为与 T2DM 发病机制相关的危险因素，但不是预测 T2DM 的理想生物标志物。
