Liu Yang, Qian Shu-Wen, Tang Yan, Tang Qi-Qun
Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Life Metab. 2024 Jan 20;3(2):loae003. doi: 10.1093/lifemeta/loae003. eCollection 2024 Apr.
In addition to their pivotal roles in energy storage and expenditure, adipose tissues play a crucial part in the secretion of bioactive molecules, including peptides, lipids, metabolites, and extracellular vesicles, in response to physiological stimulation and metabolic stress. These secretory factors, through autocrine and paracrine mechanisms, regulate various processes within adipose tissues. These processes include adipogenesis, glucose and lipid metabolism, inflammation, and adaptive thermogenesis, all of which are essential for the maintenance of the balance and functionality of the adipose tissue micro-environment. A subset of these adipose-derived secretory factors can enter the circulation and target the distant tissues to regulate appetite, cognitive function, energy expenditure, insulin secretion and sensitivity, gluconeogenesis, cardiovascular remodeling, and exercise capacity. In this review, we highlight the role of adipose-derived secretory factors and their signaling pathways in modulating metabolic homeostasis. Furthermore, we delve into the alterations in both the content and secretion processes of these factors under various physiological and pathological conditions, shedding light on potential pharmacological treatment strategies for related diseases.
除了在能量储存和消耗中发挥关键作用外，脂肪组织在响应生理刺激和代谢应激时，在生物活性分子的分泌中也起着至关重要的作用，这些生物活性分子包括肽、脂质、代谢物和细胞外囊泡。这些分泌因子通过自分泌和旁分泌机制，调节脂肪组织内的各种过程。这些过程包括脂肪生成、葡萄糖和脂质代谢、炎症和适应性产热，所有这些对于维持脂肪组织微环境的平衡和功能至关重要。这些源自脂肪的分泌因子中的一部分可以进入循环并作用于远处组织，以调节食欲、认知功能、能量消耗、胰岛素分泌和敏感性、糖异生、心血管重塑和运动能力。在这篇综述中，我们强调了源自脂肪的分泌因子及其信号通路在调节代谢稳态中的作用。此外，我们深入探讨了在各种生理和病理条件下这些因子的含量和分泌过程的变化，为相关疾病的潜在药物治疗策略提供了线索。
