Niitsu Y, Takahashi Y, Saito T, Hirata Y, Arisato N, Maruyama H, Kohgo Y, Listowsky I
Department of Internal Medicine, Sapporo Medical College, Japan.
Cancer. 1989 Jan 15;63(2):317-23. doi: 10.1002/1097-0142(19890115)63:2<317::aid-cncr2820630219>3.0.co;2-p.
A glutathione-S-transferase-pi (GST-pi) immunoradiometric assay was devised as a potential marker for serodiagnosis of malignant disease. Elevated serum GST-pi levels were observed in patients with various gastrointestinal malignancies including gastric, esophageal, colonic, pancreatic, hepatocellular, and biliary tract cancers. Patients with benign gastrointestinal diseases had normal GST-pi, but some patients with chronic hepatitis and cirrhosis had slightly elevated levels. Over 80% of patients with Stage III or IV gastric cancer and even about 50% of those with Stage I and II had elevated serum GST-pi. After surgery serum GST-pi levels returned to normal. Resected stomach cancers were immunohistochemically positive for GST-pi. During chemotherapy of colonic, gastric, and hepatocellular cancers with a series of different drugs, GST-pi changed in a biphasic manner; increases during initial phases of therapy may reflect acquisition of drug resistance by the tumor. In general, serum GST-pi assays provide a sensitive and reliable marker for gastrointestinal malignancies.
谷胱甘肽 - S - 转移酶 - π（GST - π）免疫放射分析被设计作为恶性疾病血清诊断的潜在标志物。在患有各种胃肠道恶性肿瘤的患者中观察到血清GST - π水平升高，这些肿瘤包括胃癌、食管癌、结肠癌、胰腺癌、肝细胞癌和胆管癌。患有良性胃肠道疾病的患者GST - π水平正常，但一些慢性肝炎和肝硬化患者的水平略有升高。超过80%的III期或IV期胃癌患者，甚至约50%的I期和II期患者血清GST - π升高。手术后血清GST - π水平恢复正常。切除的胃癌经免疫组织化学检测GST - π呈阳性。在用一系列不同药物对结肠癌、胃癌和肝细胞癌进行化疗期间，GST - π呈双相变化；治疗初期的升高可能反映肿瘤获得耐药性。一般来说，血清GST - π检测为胃肠道恶性肿瘤提供了一种敏感且可靠的标志物。
