Thrimurtulu Neetipalli, Khan Salman, Maity Soham, Volla Chandra M R, Maiti Debabrata
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India.
Chem Commun (Camb). 2017 Nov 16;53(92):12457-12460. doi: 10.1039/c7cc05703b.
The catalytic alkenylation of the unactivated distal γC(sp)-H bonds of aliphatic acids with simple acrylates and vinyl iodides is described. This method allows for the introduction of an alkene group into aliphatic acid derivatives in the form of activated olefins and vinyl iodides. Notably, olefination with vinyl iodides provides access to a wide range of challenging γ-vinyl acid derivatives with aliphatic olefin functionality introduced in a diastereoselective manner.
本文描述了用简单的丙烯酸酯和乙烯基碘对脂肪酸未活化的远端γC(sp)-H键进行催化烯基化反应。该方法能够以活化烯烃和乙烯基碘的形式将烯烃基团引入脂肪酸衍生物中。值得注意的是，用乙烯基碘进行烯基化反应可得到多种具有挑战性的γ-乙烯基酸衍生物，其中脂肪族烯烃官能团以非对映选择性的方式引入。
