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过渡金属催化的远端C(sp) -H官能团化的多种策略。

Diverse strategies for transition metal catalyzed distal C(sp)-H functionalizations.

作者信息

Das Jayabrata, Guin Srimanta, Maiti Debabrata

机构信息

Department of Chemistry, IIT Bombay Powai Mumbai 400076 India

出版信息

Chem Sci. 2020 Sep 28;11(40):10887-10909. doi: 10.1039/d0sc04676k.

DOI:10.1039/d0sc04676k
PMID:34094339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8162984/
Abstract

Transition metal catalyzed C(sp)-H functionalization is a rapidly growing field. Despite severe challenges, distal C-H functionalizations of aliphatic molecules by overriding proximal positions have witnessed tremendous progress. While usage of stoichiometric directing groups played a crucial role, reactions with catalytic transient directing groups or methods without any directing groups are gaining more attention due to their practicality. Various innovative strategies, slowly but steadily, circumvented issues related to remote functionalizations of aliphatic molecules. A systematic compilation has been presented here to provide insights into the recent developments and future challenges in the field. The Present perspective is expected to open up a new dimension and provide an avenue for deep insights into the distal C(sp)-H functionalizations that could be applied routinely in various pharmaceutical and agrochemical industries.

摘要

过渡金属催化的C(sp)-H官能化是一个快速发展的领域。尽管面临严峻挑战，但通过优先选择近端位置实现脂肪族分子的远端C-H官能化已取得了巨大进展。虽然化学计量导向基团的使用发挥了关键作用，但由于其实用性，与催化瞬态导向基团的反应或无任何导向基团的方法正受到更多关注。各种创新策略虽进展缓慢但稳步地规避了与脂肪族分子远程官能化相关的问题。本文进行了系统的汇编，以深入了解该领域的最新进展和未来挑战。预计本观点将开辟一个新的维度，并为深入洞察可在各种制药和农用化学品行业中常规应用的远端C(sp)-H官能化提供一条途径。

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