Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
J Am Chem Soc. 2011 Aug 24;133(33):12984-6. doi: 10.1021/ja206002m. Epub 2011 Aug 3.
The first catalytic alkynylation of unactivated C(sp(3))-H bonds has been accomplished. The method allows for the straightforward introduction of an ethynyl group into aliphatic acid derivatives under palladium catalysis. This new reaction can be applied to the rapid elaboration of complex aliphatic acids, for example, via azide/alkyne cycloaddition.
首例未活化 C(sp(3))-H 键的催化炔基化反应已经完成。该方法在钯催化下可直接将乙炔基引入脂肪酸衍生物中。这种新的反应可以应用于复杂脂肪酸的快速衍生化，例如通过叠氮化物/炔烃环加成反应。
