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NAIMS 合作试点项目:设计、实施与未来方向。

The NAIMS cooperative pilot project: Design, implementation and future directions.

机构信息

Division of Neurology, University of Toronto, Toronto, ON, Canada/Department of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.

Laboratory for Neuroimaging Research, Partners Multiple Sclerosis Center, Departments of Neurology and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

出版信息

Mult Scler. 2018 Nov;24(13):1770-1772. doi: 10.1177/1352458517739990. Epub 2017 Nov 6.

Abstract

The North American Imaging in Multiple Sclerosis (NAIMS) Cooperative represents a network of 27 academic centers focused on accelerating the pace of magnetic resonance imaging (MRI) research in multiple sclerosis (MS) through idea exchange and collaboration. Recently, NAIMS completed its first project evaluating the feasibility of implementation and reproducibility of quantitative MRI measures derived from scanning a single MS patient using a high-resolution 3T protocol at seven sites. The results showed the feasibility of utilizing advanced quantitative MRI measures in multicenter studies and demonstrated the importance of careful standardization of scanning protocols, central image processing, and strategies to account for inter-site variability.

摘要

北美多发性硬化症影像学研究(NAIMS)合作组织是一个由 27 个学术中心组成的网络,致力于通过思想交流和合作加快多发性硬化症(MS)磁共振成像(MRI)研究的步伐。最近,NAIMS 完成了第一个项目,评估了在七个地点使用高分辨率 3T 方案对单个 MS 患者进行扫描,以获得定量 MRI 测量值的实施和可重复性的可行性。结果表明,在多中心研究中使用先进的定量 MRI 测量值是可行的,并证明了仔细规范扫描方案、中央图像处理以及考虑站点间变异性的策略的重要性。

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