多部位脑 MRI 方案的可靠性和可重复性。
Multisite reliability and repeatability of an advanced brain MRI protocol.
机构信息
Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon, USA.
Neurology, Oregon Health & Science University, Portland, Oregon, USA.
出版信息
J Magn Reson Imaging. 2019 Sep;50(3):878-888. doi: 10.1002/jmri.26652. Epub 2019 Jan 16.
BACKGROUND
MRI is the imaging modality of choice for diagnosis and intervention assessment in neurological disease. Its full potential has not been realized due in part to challenges in harmonizing advanced techniques across multiple sites.
PURPOSE
To develop a method for the assessment of reliability and repeatability of advanced multisite-multisession neuroimaging studies and specifically to assess the reliability of an advanced MRI protocol, including multiband fMRI and diffusion tensor MRI, in a multisite setting.
STUDY TYPE
Prospective.
POPULATION
Twice repeated measurement of a single subject with stable relapsing-remitting multiple sclerosis (MS) at seven institutions.
FIELD STRENGTH/SEQUENCE: A 3 T MRI protocol included higher spatial resolution anatomical scans, a variable flip-angle longitudinal relaxation rate constant (R ≡ 1/T ) measurement, quantitative magnetization transfer imaging, diffusion tensor imaging, and a resting-state fMRI (rsFMRI) series.
ASSESSMENT
Multiple methods of assessing intrasite repeatability and intersite reliability were evaluated for imaging metrics derived from each sequence.
STATISTICAL TESTS
Student's t-test, Pearson's r, and intraclass correlation coefficient (ICC) (2,1) were employed to assess repeatability and reliability. Two new statistical metrics are introduced that frame reliability and repeatability in the respective units of the measurements themselves.
RESULTS
Intrasite repeatability was excellent for quantitative R , magnetization transfer ratio (MTR), and diffusion-weighted imaging (DWI) based metrics (r > 0.95). rsFMRI metrics were less repeatable (r = 0.8). Intersite reliability was excellent for R , MTR, and DWI (ICC >0.9), and moderate for rsFMRI metrics (ICC∼0.4).
DATA CONCLUSION
From most reliable to least, using a new reliability metric introduced here, MTR > R > DWI > rsFMRI; for repeatability, MTR > DWI > R > rsFMRI. A graphical method for at-a-glance assessment of reliability and repeatability, effect sizes, and outlier identification in multisite-multisession neuroimaging studies is introduced.
LEVEL OF EVIDENCE
1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:878-888.
背景
MRI 是神经疾病诊断和介入评估的首选成像方式。由于在跨多个站点协调高级技术方面存在挑战，其尚未充分发挥其全部潜力。
目的
开发一种评估高级多站点多会话神经影像学研究可靠性和可重复性的方法，特别是评估一种先进的 MRI 方案在多站点环境中的可靠性，该方案包括多带 fMRI 和弥散张量 MRI。
研究类型
前瞻性。
人群
在七个机构中，对稳定的复发缓解型多发性硬化症（MS）的单个受试者进行两次重复测量。
磁场强度/序列：3T MRI 方案包括更高空间分辨率的解剖扫描、可变翻转角纵向弛豫率常数（R≡1/T）测量、定量磁化转移成像、弥散张量成像和静息状态 fMRI（rsFMRI）系列。
评估
评估了源自每个序列的成像指标的站点内重复性和站点间可靠性的多种评估方法。
统计学检验
采用学生 t 检验、皮尔逊 r 和组内相关系数（ICC）（2,1）评估重复性和可靠性。引入了两个新的统计指标，分别以测量本身的单位来表示可靠性和重复性。
结果
定量 R、磁化转移比（MTR）和基于弥散加权成像（DWI）的指标的站点内重复性非常好（r＞0.95）。rsFMRI 指标的重复性较差（r=0.8）。R、MTR 和 DWI 的站点间可靠性非常好（ICC＞0.9），rsFMRI 指标的可靠性为中等（ICC∼0.4）。
数据结论
根据这里引入的新可靠性指标，从最可靠到最不可靠的是 MTR＞R＞DWI＞rsFMRI；对于重复性，从最可靠到最不可靠的是 MTR＞DWI＞R＞rsFMRI。引入了一种用于直观评估多站点多会话神经影像学研究中的可靠性和可重复性、效应大小和异常值识别的图形方法。
证据水平
1 技术功效：第 2 阶段 J. Magn. Reson. Imaging 2019；50:878-888.
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