Dhinaut Julien, Chogne Manon, Moret Yannick
Université de Bourgogne Franche-Comté, UMR CNRS 6282 Biogéosciences, équipe Ecologie Evolutive, 6 Boulevard Gabriel, Dijon, France.
Université de Bourgogne Franche-Comté, UMR CNRS 6282 Biogéosciences, équipe Ecologie Evolutive, 6 Boulevard Gabriel, Dijon, France.
Dev Comp Immunol. 2018 Feb;79:105-112. doi: 10.1016/j.dci.2017.10.017. Epub 2017 Oct 26.
Immune-challenged mothers can improve their offspring immunity through trans-generational immune priming (TGIP). In insects, TGIP endows the offspring with lifetime immunity, including the eggs, which are likely exposed soon after maternal infection. Egg protection may rely on the transfer of maternal immune effectors to the egg or/and the induction of egg immune genes. These respective mechanisms are assumed to have early-life fitness costs of different magnitude for the offspring. We provide evidence in the mealworm beetle Tenebrio molitor that enhanced egg immunity following a maternal immune challenge is achieved by both of these mechanisms but in a pathogen-dependent manner. While previously found having late-life fitness costs for the offspring, TGIP here improved egg hatching success and early larval survival, in addition of improving offspring immunity. These results suggest that early-life of primed offspring is critical in the optimization of life history trajectory of this insect under trans-generational pathogenic threats.
免疫受到挑战的母亲可以通过跨代免疫致敏（TGIP）来提高其后代的免疫力。在昆虫中，TGIP赋予后代终身免疫力，包括卵，母体感染后卵可能很快就会暴露。卵的保护可能依赖于母体免疫效应物向卵的转移或/和卵免疫基因的诱导。假定这些各自的机制对后代具有不同程度的早期生活适应性成本。我们在黄粉虫Tenebrio molitor中提供了证据，表明母体免疫挑战后增强的卵免疫力是通过这两种机制实现的，但以病原体依赖的方式。虽然之前发现对后代有后期生活适应性成本，但这里的TGIP除了提高后代免疫力外，还提高了卵的孵化成功率和幼虫早期存活率。这些结果表明，在跨代致病威胁下，致敏后代的早期生活对于优化这种昆虫的生活史轨迹至关重要。
