Dutta S K, Dukehart M, Narang A, Latham P S
Department of Medicine, Veterans Administration Medical Center, Baltimore, Maryland.
Gastroenterology. 1989 Feb;96(2 Pt 1):510-8. doi: 10.1016/0016-5085(89)91578-3.
The parotid gland function and structure was studied in 30 patients with biopsy-proven alcoholic cirrhosis and in 43 age- and sex-matched alcoholic and nonalcoholic control subjects. Mean simulated parotid saliva flow rate was significantly (p less than 0.05) lower in patients with alcoholic cirrhosis as compared with alcoholic and nonalcoholic control subjects. A similar reduction was observed in mean basal parotid saliva flow rate in patients with alcoholic cirrhosis that reached statistical significance (p less than 0.05) in comparison with nonalcoholic control subjects. In addition, the concentration of sodium, bicarbonate, and total proteins in stimulated parotid saliva was significantly (p less than 0.005) lower in patients with alcoholic cirrhosis as compared with the two groups of control subjects. Sialograms in 6 patients with alcoholic cirrhosis did not reveal any obstructive lesion in the primary parotid duct or its branches. Histology of salivary tissue revealed an increase in the interstromal fatty infiltration, edema, and fibrosis without evidence of inflammatory reaction in 5 patients as compared with the control subjects. These data provide evidence for marked parotid gland dysfunction in patients with alcoholic cirrhosis presumably due to metabolic derangement and altered parotid gland structure.
对30例经活检证实为酒精性肝硬化的患者以及43例年龄和性别匹配的酒精性和非酒精性对照受试者的腮腺功能和结构进行了研究。与酒精性和非酒精性对照受试者相比，酒精性肝硬化患者的平均模拟腮腺唾液流速显著降低（p<0.05）。酒精性肝硬化患者的平均基础腮腺唾液流速也有类似降低，与非酒精性对照受试者相比达到统计学显著性（p<0.05）。此外，与两组对照受试者相比，酒精性肝硬化患者刺激腮腺唾液中的钠、碳酸氢盐和总蛋白浓度显著降低（p<0.005）。6例酒精性肝硬化患者的腮腺造影未显示腮腺主导管或其分支有任何阻塞性病变。与对照受试者相比，5例患者的唾液组织组织学显示间质脂肪浸润、水肿和纤维化增加，无炎症反应迹象。这些数据为酒精性肝硬化患者存在明显的腮腺功能障碍提供了证据，推测这是由于代谢紊乱和腮腺结构改变所致。
