Kolker Shimon, Tzivoni Dan, Rosenmann David, Meyler Shmuel, Ioscovich Alexander
Department of Cardiology, Perioperative Medicine and Pain Treatment, Shaare-Zedek Medical Center, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
Department of Anesthesiology, Perioperative Medicine and Pain Treatment, Shaare-Zedek Medical Center, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
J Anaesthesiol Clin Pharmacol. 2017 Jul-Sep;33(3):402-405. doi: 10.4103/0970-9185.173337.
Neostigmine is a cholinesterase inhibitor which does not cross the blood brain barrier and a commonly used for reversal of nondepolarizing muscle relaxants. In the following case report, we present a patient who developed coronary artery spasm, after the administration of repeated doses of neostigmine. Ours is the first case to demonstrate such a longstanding coronary artery vasospasm that lasted several hours in response to neostigmine, resulting in myocardial damage and left ventricular dysfunction. We would like to draw the attention of the anesthesiologists to this rare effect that may lead to perioperative cardiac complications.
新斯的明是一种胆碱酯酶抑制剂，不能穿过血脑屏障，常用于逆转非去极化肌松药的作用。在以下病例报告中，我们呈现了一名患者，在重复给予新斯的明后发生了冠状动脉痉挛。我们的病例是首例证明新斯的明引发如此长时间冠状动脉血管痉挛（持续数小时）的病例，导致心肌损伤和左心室功能障碍。我们希望引起麻醉医生对这种可能导致围手术期心脏并发症的罕见效应的关注。
