Karimian Negin, Yeh Heidi
Division of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Center for Engineering in Medicine, Harvard Medical School, Boston, USA.
Curr Transplant Rep. 2017 Jun;4(2):141-148. doi: 10.1007/s40472-017-0144-y. Epub 2017 Apr 19.
There is a vast discrepancy between the number of patients waiting for organ transplantation and the available donor organs. machine perfusion (MP) has emerged in an effort to expand the donor pool, by improving organ preservation, providing diagnostic information, and more recently, acting as a platform for organ improvement. This article reviews the current status of MP with a focus on its role in organ preconditioning and therapeutic interventions prior to transplantation.
MP has allowed longer organ preservation compared to conventional static cold storage and allowed the use of organs that might otherwise have been discarded. Moreover, experimental studies have investigated the role of MP in reducing ischemia reperfusion injury of lungs, kidneys and livers by applying mesenchymal stem cells (MSCs), anti-inflammatory agents, cytotopic anticoagulants, and defatting cocktails.
MP has opened a new era in the field of organ transplantation and tissue medication.
等待器官移植的患者数量与可用的供体器官数量之间存在巨大差异。机器灌注（MP）已出现，旨在通过改善器官保存、提供诊断信息以及最近作为器官改善的平台来扩大供体库。本文回顾了MP的现状，重点关注其在移植前器官预处理和治疗干预中的作用。
与传统的静态冷藏相比，MP能够实现更长时间的器官保存，并允许使用那些原本可能被丢弃的器官。此外，实验研究通过应用间充质干细胞（MSC）、抗炎剂、局部抗凝剂和去脂混合物，探讨了MP在减轻肺、肾和肝脏缺血再灌注损伤中的作用。
MP开启了器官移植和组织药物治疗领域的新纪元。
