Jenkins Lisanne M, Stange Jonathan P, Barba Alyssa, DelDonno Sophie R, Kling Leah R, Briceño Emily M, Weisenbach Sara L, Phan K Luan, Shankman Stewart A, Welsh Robert C, Langenecker Scott A
Department of Psychiatry, The University of Illinois at Chicago, Chicago, USA.
Department of Psychiatry, The University of Michigan, Ann Arbor, USA.
Cogn Affect Behav Neurosci. 2017 Dec;17(6):1242-1254. doi: 10.3758/s13415-017-0547-3.
Emotion perception deficits could be due to disrupted connectivity of key nodes in the salience and emotion network (SEN), including the amygdala, subgenual anterior cingulate cortex (sgACC), and insula. We examined SEN resting-state (rs-)fMRI connectivity in rMDD in relation to Facial Emotion Perception Test (FEPT) performance. Fifty-two medication-free people ages 18 to 23 years participated. Twenty-seven had major depressive disorder (MDD) in remission (rMDD, 10 males), as MDD is associated with emotion perception deficits and alterations in rsfMRI. Twenty-five healthy controls (10 males) also participated. Participants completed the FEPT during fMRI, in addition to an 8-minute eyes-open resting-state scan. Seed regions of interest were defined in the amygdala, anterior insula and sgACC. Multiple regression analyses co-varied diagnostic group, sex and movement parameters. Emotion perception accuracy was positively associated with connectivity between amygdala seeds and regions primarily in the SEN and cognitive control network (CCN), and also the default mode network (DMN). Accuracy was also positively associated with connectivity between the sgACC seeds and other SEN regions, and the DMN, particularly for the right sgACC. Connectivity negatively associated with emotion perception was mostly with regions outside of these three networks, other than the left insula and part of the DMN. This study is the first to our knowledge to demonstrate relationships between facial emotion processing and resting-state connectivity with SEN nodes and between SEN nodes and regions located within other neural networks.
情绪感知缺陷可能是由于突显和情绪网络（SEN）中关键节点的连接中断所致，这些节点包括杏仁核、膝下前扣带回皮质（sgACC）和脑岛。我们研究了缓解期重度抑郁症（rMDD）患者的SEN静息态（rs-）功能磁共振成像（fMRI）连接性与面部情绪感知测试（FEPT）表现之间的关系。52名年龄在18至23岁之间且未服用药物的人参与了研究。其中27人患有缓解期重度抑郁症（rMDD，10名男性），因为重度抑郁症与情绪感知缺陷和rsfMRI改变有关。另外25名健康对照者（10名男性）也参与了研究。参与者在功能磁共振成像期间完成了FEPT，此外还进行了一次8分钟的睁眼静息态扫描。在杏仁核、前脑岛和sgACC中定义了感兴趣的种子区域。多元回归分析对诊断组、性别和运动参数进行了协变量调整。情绪感知准确性与杏仁核种子与主要位于SEN和认知控制网络（CCN）以及默认模式网络（DMN）中的区域之间的连接性呈正相关。准确性还与sgACC种子与其他SEN区域以及DMN之间的连接性呈正相关，特别是右侧sgACC。与情绪感知呈负相关的连接主要是与这三个网络之外的区域，除了左侧脑岛和部分DMN。据我们所知，这项研究首次证明了面部情绪处理与SEN节点的静息态连接性之间以及SEN节点与其他神经网络内区域之间的关系。
