Parkin A, Smye S W, Bishop N, Wilkinson D, Rees M, Vowden P, Kester R C
Department of Medical Physics, St James's University Hospital, United Kingdom, Leeds.
J Nucl Med. 1989 Jan;30(1):45-50.
A simple, low cost method for measuring forearm blood flow during reactive hyperemia has been developed. Subjects are seated with hands and forearms over a large field-of-view gamma camera. Blood pressure cuffs inflated above the elbows isolate the blood in the forearms and hands and induce a hyperemic response. The remaining blood pool is labeled with technetium. The rate of increase of activity following release of the cuffs is measured from the gradient of time-activity curves and is calibrated for flow by counting a venous blood sample. The technique has been applied to a group of normal controls and to symptomatic and asymptomatic patients following right brachial arteriotomy. Forearm blood flow in normal subjects was 32.9 +/- 6.4 ml/100 ml/min and for subjects with occlusion of the brachial artery was 6.4 +/- 2.1 ml/100 ml/min. The method is simple, widely available, and reproducible. The good signal to noise ratio allows it to be used in cases of very low flow either as an aid to diagnosis or to measure treatment response.
已开发出一种简单、低成本的测量反应性充血期间前臂血流量的方法。受试者就座，将手和前臂置于大视野伽马相机上方。肘部上方充气的血压袖带隔离前臂和手部的血液并引发充血反应。剩余血池用锝标记。通过时间-活性曲线的斜率测量袖带松开后活性的增加速率，并通过对静脉血样本计数来校准血流量。该技术已应用于一组正常对照以及右肱动脉切开术后有症状和无症状的患者。正常受试者的前臂血流量为32.9±6.4 ml/100 ml/分钟，肱动脉闭塞的受试者为6.4±2.1 ml/100 ml/分钟。该方法简单、广泛可用且可重复。良好的信噪比使其能够用于极低流量的情况，作为诊断辅助或测量治疗反应。
