Wilkinson D, Parkin A, Wowden P, Robinson P J, Kester R C
Department of Vascular Surgery, St. James's University, Leeds, U.K.
J Cardiovasc Surg (Torino). 1989 Jul-Aug;30(4):618-23.
To evaluate a new method for limb blood flow measurement using a radioactive isotope and a gamma camera, blood flow measurements have ben made on 108 patients with peripheral vascular disease. Thirty-six patients had ischaemic rest pain, of whom two had previously undergone unilateral amputation. Five had bilateral symptoms, giving 29 asymptomatic limbs and 41 limbs with critical ischaemia. In 72 patients with intermittent claudication a series of exercise tests were attempted, in 33 these were unsatisfactory; 13 patients had a greater than 20% variability in the maximum walking distance between four tests and in 20 walking distance was limited by factors other than claudication. In these 33 patients the limb blood flow to the symptomatic leg was 3.95 (1.36-11.08) ml/100 ml of tissue/minute. This is not significantly different from the limb blood flow to the symptomatic leg of the 39 patients who satisfactorily completed four exercise tests, 3.75 (1.08-8.25) ml/100 ml of tissue/minute. In these 39 patients the mean pain-free walking distance was 40 metres and the mean maximum walking distance was 63 metres. The limb blood flow to the 41 symptomatic limbs of 36 patients with rest pain was 1.90 (0.90-4.49) ml/100 ml of tissue/minute, which is significantly less than that obtained in claudicants. There was a wide range of blood flow values found in the asymptomatic limbs of all the patients and in many cases the flow was markedly reduced from normal. This method of limb blood flow measurement is accurate and reproducible and may be recommended for assessment of peripheral vascular disease.
为评估一种使用放射性同位素和伽马相机测量肢体血流的新方法，对108例周围血管疾病患者进行了血流测量。36例患者有静息性缺血性疼痛，其中2例先前接受过单侧截肢。5例有双侧症状，即29条无症状肢体和41条严重缺血肢体。在72例间歇性跛行患者中尝试进行了一系列运动试验，其中33例结果不理想；13例患者在四次试验之间最大行走距离的变异性大于20%，20例患者的行走距离受跛行以外的因素限制。在这33例患者中，有症状腿部的肢体血流为3.95（1.36 - 11.08）ml/100 ml组织/分钟。这与39例顺利完成四次运动试验患者有症状腿部的肢体血流3.75（1.08 - 8.25）ml/100 ml组织/分钟无显著差异。在这39例患者中，平均无痛行走距离为40米，平均最大行走距离为63米。36例有静息性疼痛患者的41条有症状肢体的肢体血流为1.90（0.90 - 4.49）ml/100 ml组织/分钟，明显低于间歇性跛行患者。在所有患者的无症状肢体中发现了广泛的血流值范围，在许多情况下血流较正常明显降低。这种肢体血流测量方法准确且可重复，可推荐用于评估周围血管疾病。
