无金属有氧三级胺的氰化反应：偶氮二异丁腈（AIBN）作为唯一的氰源。
Metal-Free Aerobic Oxidative Cyanation of Tertiary Amines: Azobis(isobutyronitrile) (AIBN) as a Sole Cyanide Source.
机构信息
College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University , Dandong Lu West 1, Fushun 113001, China.
出版信息
J Org Chem. 2017 Dec 1;82(23):12786-12790. doi: 10.1021/acs.joc.7b02021. Epub 2017 Nov 17.
PMID:29110484
Abstract
An aerobic oxidative cyanation for the synthesis of α-aminonitriles was reported. The formation of C(sp)-CN bonds was achieved under a metal-free condition by utilizing azobis(isobutyronitrile) as a sole organic cyanide source with the combination of pivalic acid and sodium acetate as additives.
摘要
本文报道了一种有氧氧化氰化法用于合成α-氨基腈。在无金属条件下，利用偶氮二异丁腈作为唯一的有机氰源，并结合特戊酸和醋酸钠作为添加剂，实现了 C(sp)-CN 键的形成。
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