Quintavalla Arianna
Department of Chemistry "G. Ciamician", Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Curr Med Chem. 2018;25(8):917-962. doi: 10.2174/0929867324666171106162259.
The spirocyclic compounds have always aroused a great interest because this motif is present as structural core in a number of natural products and bioactive compounds. In particular, the spirolactone moiety has been recognized in a wide array of natural and non-natural scaffolds showing a variety of useful pharmacological properties.
Extensive literature search using SciFinder (Databases: CA Plus, CAS Registry, CAS React, Chemlist, Chemcat and Medline) and Web of Science (Database: Web of Science Core Collection) was conducted.
Nowadays, many efforts are being devoted to the discovery of new natural products containing the promising spirolactone framework and to the disclosure of the potential bioactivities of these chemical entities. Moreover, the medicinal relevance of many spirolactones makes these scaffolds attractive targets for the design and development of innovative and efficient synthetic strategies, enabling the construction of complex and variably substituted products.
This review gives an overview on the recent advances in the spirolactones field, in terms of new compounds isolated from natural sources, recently determined bioactivity profiles and innovative synthetic approaches. The collected data demonstrate the key role played by spirolactones in medicinal chemistry and the great attention still devoted by the scientific community to these compounds.
螺环化合物一直备受关注，因为该结构单元在许多天然产物和生物活性化合物中作为结构核心存在。特别是，螺内酯部分已在大量天然和非天然骨架中被识别，显示出多种有用的药理特性。
使用SciFinder（数据库：CA Plus、CAS Registry、CAS React、Chemlist、Chemcat和Medline）和Web of Science（数据库：Web of Science核心合集）进行了广泛的文献检索。
如今，许多研究致力于发现含有有前景的螺内酯骨架的新天然产物，并揭示这些化学实体的潜在生物活性。此外，许多螺内酯的药用相关性使这些骨架成为设计和开发创新高效合成策略的有吸引力的目标，能够构建复杂且具有不同取代基的产物。
本综述概述了螺内酯领域的最新进展，包括从天然来源分离的新化合物、最近确定的生物活性概况和创新的合成方法。收集的数据证明了螺内酯在药物化学中所起的关键作用，以及科学界对这些化合物仍给予的高度关注。
