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原发性晶状体囊膜小梁切开术/小梁切开术对正常眼压性青光眼患者眼压的影响:3年结果

Effect of primary Phacoviscocanalostomy/ Viscocanalostomy on intraocular pressure of normal tension glaucoma patients: 3-year results.

作者信息

Ho Derek Kwun-Hong, Garrick Adesuwa, Aazem Seemeen, Mathews Divya

机构信息

Stanley Eye Unit, Abergele Hospital, Llanfair Road, Abergele, Conwy, LL22 8DP, UK.

出版信息

BMC Ophthalmol. 2017 Nov 6;17(1):201. doi: 10.1186/s12886-017-0596-y.

DOI:10.1186/s12886-017-0596-y
PMID:29110658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5674681/
Abstract

BACKGROUND

The objective of this study was to evaluate the efficacy of Viscocanalostomy/Phacoviscocanalostomy (VC/PVC) in lowering intraocular pressure (IOP) in Normal Tension Glaucoma (NTG) patients.

METHODS

Retrospective electronic database review of patients who underwent VC/PVC for NTG between December 2009 and November 2011 at Stanley eye unit in Abergele Hospital. Goldmann applanation tonometry (GAT) was used for all IOP measurements which were taken at the time of listing for surgery and at 1 day, 1 week, 1 month, then 3-monthly up to 1 year, then half-yearly up to 3 years post operatively. Statistical analysis was performed using unpaired t-test. A P value of <0.05 was accepted as the level of significance.

RESULTS

Operations were performed on 94 eyes from 67 patients over the study period. The mean age at the time of surgery was 76.4 years. Pre-operative IOP was 17.75 ± 2.19 mmHg (range 12-21 mmHg). 3 year follow-up showed a mean IOP of 13.41 ± 2.22 mmHg (range 8-18 mmHg). By year 3, 17 patients needed laser goniopuncture and 25 patients needed antiglaucoma drops. IOP was reduced by 24.4% at 3 years post-surgery, which was statistically significant (p < 0.0001).

CONCLUSIONS

From our results, which show a 24.5% reduction in IOP at 3 years with 12% complication rate, we propose that a logical surgical management for NTG patients would be viscocanalostomy, thereby keeping trabeculectomy as an alternative.

摘要

背景

本研究的目的是评估粘小管切开术/晶状体粘小管切开术(VC/PVC)降低正常眼压性青光眼(NTG)患者眼压(IOP)的疗效。

方法

对2009年12月至2011年11月期间在阿伯盖尔医院斯坦利眼科接受NTG的VC/PVC手术的患者进行回顾性电子数据库审查。所有眼压测量均使用Goldmann压平眼压计(GAT),在手术登记时以及术后1天、1周、1个月,然后每3个月直至1年,之后每半年直至3年进行测量。采用不成对t检验进行统计分析。P值<0.05被视为具有统计学意义。

结果

在研究期间,对67例患者的94只眼进行了手术。手术时的平均年龄为76.4岁。术前眼压为17.75±2.19 mmHg(范围12 - 21 mmHg)。3年随访显示平均眼压为13.41±2.22 mmHg(范围8 - 18 mmHg)。到第3年,17例患者需要激光房角穿刺,25例患者需要使用抗青光眼滴眼液。术后3年眼压降低了24.4%,具有统计学意义(p < 0.0001)。

结论

我们的结果显示,3年时眼压降低了24.5%,并发症发生率为12%,我们建议对NTG患者进行合理的手术管理应为粘小管切开术,从而将小梁切除术作为一种替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6133/5674681/acecdd903499/12886_2017_596_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6133/5674681/2c3ee8b6087c/12886_2017_596_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6133/5674681/a5d72b14b621/12886_2017_596_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6133/5674681/acecdd903499/12886_2017_596_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6133/5674681/2c3ee8b6087c/12886_2017_596_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6133/5674681/a5d72b14b621/12886_2017_596_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6133/5674681/acecdd903499/12886_2017_596_Fig3_HTML.jpg

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本文引用的文献

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Acta Ophthalmol. 2015 Jun;93(4):362-7. doi: 10.1111/aos.12513. Epub 2014 Oct 1.
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Safety And Efficacy Of Achieving Single-Digit Intraocular Pressure Targets With Filtration Surgery In Eyes With Progressive Normal-Tension Glaucoma.滤过手术使进展性正常眼压性青光眼患者眼压降至个位数目标值的安全性和有效性
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New directions in the treatment of normal tension glaucoma.
正常眼压性青光眼治疗的新方向。
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Nd: YAG laser goniopuncture: indications and procedure.Nd:YAG 激光前房角穿刺术:适应证和操作步骤。
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Post-operative management of trabeculectomy in the first three months.小梁切除术术后前三个月的管理
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The effect of deep sclerectomy on intraocular pressure of normal-tension glaucoma patients: 1-year results.深巩膜切除术对正常眼压性青光眼患者眼压的影响:1 年结果。
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Nonpenetrating glaucoma surgery: meta-analysis of recent results.非穿透性青光眼手术:近期结果的荟萃分析
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