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晚期青光眼患者行粘小管切开术和超声乳化粘小管切开术的疗效

Outcomes of viscocanalostomy and phaco-viscocanalostomy in patients with advanced glaucoma.

作者信息

Tsagkataki M, Bampouras T M, Choudhary A

机构信息

Royal Liverpool University Hospital, Liverpool, L7 8XP, UK.

Active Ageing Research Group, Department of Medical and Sport Sciences, University of Cumbria, Lancaster, England.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2018 Aug;256(8):1481-1487. doi: 10.1007/s00417-018-4010-0. Epub 2018 May 22.

Abstract

PURPOSE

To determine the medium-term outcomes for patients with advanced glaucoma undergoing viscocanalostomy.

METHODS

All patients with advanced glaucoma (mean deviation (MD) - 12.00 dB or above) and patients with poor visual acuity secondary to advanced glaucoma which precluded formal visual field assessment undergoing viscocanalostomy (VC) and phaco-viscocanalostomy between 2010 and 2014 under the care of a single surgical team were included. Intraocular pressure (IOP), visual acuity (VA) and visual field outcomes were assessed from data prospectively collected into a surgical outcome database. Success was defined at two IOP cut-off points: IOP ≤ 21 and ≤ 16 mmHg with (qualified) or without (complete) medications.

RESULTS

One hundred thirty-five patients were included. Mean IOP changed from 23.6 ± 6.4 mmHg pre-operatively to 15.3, 15.8 and 14.8 mmHg at 1, 2 and 3 years, a change of 35, 33.5 and 39% respectively. Qualified success for an IOP ≤ 21 mmHg was achieved in 95.66, 90.6 and 80% and complete success in 52.5, 48.6 and 30.6% at year 1, 2 and 3. Qualified success for an IOP ≤ 16 mmHg was achieved in 66.6, 66.05 and 60% and complete success in 44.8, 37.6 and 30.6% at year 1, 2 and 3. The cumulative probability for achieving an IOP ≤ 21 mmHg with or without drops was 86.1, 81.4 and 81.4% at 12, 24 and 36 months. Eleven patients (8.1%) failed to achieve adequate IOP control and needed further surgical intervention. Eleven (8.1%) patients needed an intervention (Yag goniopuncture) following VC. Four patients (2.9%) had some post-operative complications, which resolved within 2 weeks following surgery. Nine patients (6.7%) lost more than 2 Snellen lines. There was no significant change in the MD across time points.

CONCLUSION

Viscocanalostomy and viscocanalostomy combined with phacoemulsification is a safe and effective method of controlling IOP in the medium term in patients with advanced glaucoma.

摘要

目的

确定接受粘小管成形术的晚期青光眼患者的中期治疗效果。

方法

纳入2010年至2014年期间在单一手术团队治疗下,所有患有晚期青光眼(平均偏差(MD)-12.00 dB及以上)以及因晚期青光眼导致视力差而无法进行正规视野评估的患者,这些患者接受了粘小管成形术(VC)和超声乳化粘小管成形术。从前瞻性收集到手术结果数据库的数据中评估眼压(IOP)、视力(VA)和视野结果。成功的定义基于两个眼压切点:使用(合格)或不使用(完全)药物治疗时眼压≤21和≤16 mmHg。

结果

共纳入135例患者。平均眼压术前为23.6±6.4 mmHg,术后1年、2年和3年分别变为15.3、15.8和14.8 mmHg,变化率分别为35%、33.5%和39%。1年、2年和3年时,眼压≤21 mmHg的合格成功率分别为95.66%、90.6%和80%,完全成功率分别为52.5%、48.6%和30.6%。1年、2年和3年时,眼压≤16 mmHg的合格成功率分别为66.6%、66.05%和60%,完全成功率分别为44.8%、37.6%和30.6%。使用或不使用降眼压药物时,眼压≤21 mmHg的累积概率在12个月、24个月和36个月时分别为86.1%、81.4%和81.4%。11例患者(8.1%)未能实现充分的眼压控制,需要进一步手术干预。VC术后有11例(8.1%)患者需要进行干预(Yag房角穿刺)。4例患者(2.9%)出现一些术后并发症,术后2周内缓解。9例患者(6.7%)视力下降超过2行Snellen视力表。各时间点的MD无显著变化。

结论

粘小管成形术以及粘小管成形术联合超声乳化术是控制晚期青光眼患者中期眼压的一种安全有效的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea6/6060749/2ee893bce8f9/417_2018_4010_Fig1_HTML.jpg

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