RIKEN Brain Science Institute, Laboratory for Molecular Mechanisms of Thalamus Development, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
RIKEN Brain Science Institute, Laboratory for Molecular Mechanisms of Thalamus Development, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Neurosci Res. 2018 Mar;128:1-13. doi: 10.1016/j.neures.2017.10.009. Epub 2017 Oct 27.
Interest in the common marmoset (Callithrix jacchus) as a primate model animal has grown recently, in part due to the successful demonstration of transgenic marmosets. However, there is some debate as to the suitability of marmosets, compared to more widely used animal models, such as the macaque monkey and mouse. Especially, the usage of marmoset for animal models of human cognition and mental disorders, is still yet to be fully explored. To examine the prospects of the marmoset model for neuroscience research, the Marmoset Gene Atlas (https://gene-atlas.bminds.brain.riken.jp/) provides a whole brain gene expression atlas in the common marmoset. We employ in situ hybridization (ISH) to systematically analyze gene expression in neonate marmoset brains, which allows us to compare expression with other model animals such as mouse. We anticipate that these data will provide sufficient information to develop tools that enable us to reveal marmoset brain structure, function, cellular and molecular organization for primate brain research.
人们对普通狨猴（Callithrix jacchus）作为灵长类动物模型的兴趣最近有所增加，部分原因是成功展示了转基因狨猴。然而，与更广泛使用的动物模型（如猕猴和小鼠）相比，狨猴的适用性仍存在一些争议。特别是，狨猴在人类认知和精神障碍的动物模型中的应用仍有待充分探索。为了研究狨猴模型在神经科学研究中的前景，狨猴基因图谱（https://gene-atlas.bminds.brain.riken.jp/）提供了普通狨猴全脑基因表达图谱。我们采用原位杂交（ISH）技术系统地分析新生狨猴大脑中的基因表达情况，这使我们能够与其他模型动物（如小鼠）进行比较。我们预计这些数据将提供足够的信息来开发工具，使我们能够揭示狨猴大脑的结构、功能、细胞和分子组织，从而促进灵长类动物大脑研究。
