Ma Shuang-Gang, Yuan Shao-Peng, Liu Yun-Bao, Qu Jing, Li Yong, Wang Xiao-Jing, Wang Ru-Bing, Xu Song, Hou Qi, Yu Shi-Shan
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Fitoterapia. 2018 Jan;124:80-85. doi: 10.1016/j.fitote.2017.10.017. Epub 2017 Oct 27.
Three new 3-hydroxy-3-methylglutaryl (HMG) flavone 7-O-diglycosides, argutosides A-C (1-3); two new flavone 7-O-triglycosides, argutosides D-E (4-5); and one known apigenin 7-O-triglycoside (6), were isolated from the leaves of Turpinia arguta. The structures of these compounds were elucidated by spectroscopic and chemical techniques. The NO inhibitory activities of compounds 1-6 were evaluated using lipopolysaccharide-induced RAW264.7 cells. Only compound 2 showed a moderate inhibitory effect on NO production with an IC value of 25.74μM. Compounds 1-6 were not cytotoxic to RAW264.7 cells at 10μM.
从山香圆叶中分离得到3个新的3-羟基-3-甲基戊二酰（HMG）黄酮7-O-二糖苷，即山香圆苷A - C（1 - 3）；2个新的黄酮7-O-三糖苷，即山香圆苷D - E（4 - 5）；以及1个已知的芹菜素7-O-三糖苷（6）。通过光谱和化学技术阐明了这些化合物的结构。使用脂多糖诱导的RAW264.7细胞评估了化合物1 - 6的一氧化氮（NO）抑制活性。只有化合物2对NO生成表现出中等抑制作用，IC值为25.74μM。化合物1 - 6在10μM时对RAW264.7细胞无细胞毒性。
