Hu Yue, Jiao Lin, Jiang Min-Hong, Yin Sheng, Dong Pan, Zhao Zhi-Min, Yang De-Po, Ho Pei-Tsai, Wang Dong-Mei
a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou , P. R. China.
b Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou , P. R. China.
Nat Prod Res. 2018 Oct;32(19):2312-2318. doi: 10.1080/14786419.2017.1410809. Epub 2017 Dec 4.
A new C-glycosyl flavone, Chrysin-8-C-(2″-O-β-6-deoxy-glucopyranosyl)-β-D-glucopyranoside (1), a new neolignan glycoside, citrusin G (2), as well as 15 known compounds (3-17) were isolated from the peel of Passiflora edulis Sims. The structure determinations were primarily based on comprehensive spectroscopic analyses, and the absolute configuration of 2 were unequivocally determined by the CD experiment and chemical transformation. Compound 1 represents the rare examples of the flavonoid featuring a deoxy glucose sugar moiety. Compounds 5, 7 and 9 exhibited moderate inhibitory effects on nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells, with IC values of 34.92, 16.12 and 26.67 μM, respectively.
从西番莲果皮中分离得到一个新的C-糖基黄酮，白杨素-8-C-(2″-O-β-6-脱氧吡喃葡萄糖基)-β-D-吡喃葡萄糖苷(1)、一个新的新木脂素糖苷，柑橘苷G(2)，以及15个已知化合物(3 - 17)。结构鉴定主要基于综合光谱分析，2的绝对构型通过圆二色光谱实验和化学转化明确确定。化合物1是具有脱氧葡萄糖糖部分的黄酮类化合物的罕见例子。化合物5、7和9对RAW 264.7细胞中脂多糖(LPS)刺激产生的一氧化氮(NO)有中等程度的抑制作用，IC值分别为34.92、16.12和26.67 μM。
