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本文引用的文献

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Liquid biopsies come of age: towards implementation of circulating tumour DNA.液体活检时代的到来：迈向循环肿瘤 DNA 的临床应用。
Nat Rev Cancer. 2017 Apr;17(4):223-238. doi: 10.1038/nrc.2017.7. Epub 2017 Feb 24.
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SnapShot: Circulating Tumor Cells.Snapshot：循环肿瘤细胞。
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Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.克隆异质性与肿瘤演进：过去、现在与未来。
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Precision oncology for acute myeloid leukemia using a knowledge bank approach.采用知识库方法的急性髓系白血病精准肿瘤学
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A 17-gene stemness score for rapid determination of risk in acute leukaemia.一种用于快速确定急性白血病风险的 17 基因干性评分。
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Vasculogenic mimicry in small cell lung cancer.小细胞肺癌中的血管生成拟态。
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Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma.单细胞RNA测序支持人类少突胶质细胞瘤的发育层次结构。
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Measuring cancer evolution from the genome.从基因组测量癌症进化。
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Genomic Classification and Prognosis in Acute Myeloid Leukemia.急性髓系白血病的基因组分类与预后
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Big data visualization identifies the multidimensional molecular landscape of human gliomas.大数据可视化识别出人类胶质瘤的多维分子格局。
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血液系统恶性肿瘤和实体瘤中的肿瘤内异质性与克隆进化。

Intratumoral heterogeneity and clonal evolution in blood malignancies and solid tumors.

作者信息

Varela Ignacio, Menendez Pablo, Sanjuan-Pla Alejandra

机构信息

Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria-CSIC, Santander, Spain.

Department of Biomedicine, Josep Carreras Leukemia Research Institute, School of Medicine, University of Barcelona, Barcelona, Spain.

出版信息

Oncotarget. 2017 Aug 16;8(39):66742-66746. doi: 10.18632/oncotarget.20279. eCollection 2017 Sep 12.

DOI:10.18632/oncotarget.20279
PMID:29112206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5630451/
Abstract

This meeting held at the University of Barcelona in March 2017, brought together scientists and clinicians worldwide to discuss current and future clinico-biological implications of intratumoral heterogeneity (ITH) and subclonal evolution in cancer diagnosis, patient stratification, and treatment resistance in diagnosis, treatment and follow-up. There was consensus that both longitudinal and tumor multi-region studies in matched samples are needed to better understand the dynamics of ITH. The contribution of the epigenome and microenvironment to ITH and subclone evolution remains understudied. It was recommended to combine computational, pathology and imaging tools to study the role of the microenvironment in subclone selection/evolution.

摘要

2017年3月在巴塞罗那大学召开的本次会议，汇聚了全球的科学家和临床医生，共同探讨肿瘤内异质性（ITH）和亚克隆进化在癌症诊断、患者分层以及诊断、治疗和随访中的治疗抵抗方面的当前及未来临床生物学意义。与会者达成共识，认为需要对匹配样本进行纵向和肿瘤多区域研究，以更好地理解ITH的动态变化。表观基因组和微环境对ITH及亚克隆进化的作用仍未得到充分研究。会议建议结合计算、病理学和成像工具，研究微环境在亚克隆选择/进化中的作用。