The "Never-Ending" Mouse Models for MLL-Rearranged Acute Leukemia Are Still Teaching Us.
作者信息
Ottersbach Katrin, Sanjuan-Pla Alejandra, Torres-Ruíz Raúl, Bueno Clara, Velasco-Hernández Talia, Menendez Pablo
机构信息
MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
Hematology Research Group, IIS La Fe, Valencia, Spain.
出版信息
Hemasphere. 2018 Jun 19;2(4):e57. doi: 10.1097/HS9.0000000000000057. eCollection 2018 Aug.
Abstract
摘要
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leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing.利用基因组编辑技术在人造血干细胞中诱导 t(9;11)染色体易位所致白血病。
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The AF4-MLL fusion transiently augments multilineage hematopoietic engraftment but is not sufficient to initiate leukemia in cord blood CD34 cells.AF4-MLL融合蛋白可短暂增强多谱系造血植入，但不足以在脐血CD34细胞中引发白血病。
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