Équipe "Pharmacognosie-Chimie des substances naturelles" BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay , 5 rue J.-B. Clément, 92290 Châtenay-Malabry, France.
Laboratoire de microbiologie, Université des Sciences et Techniques de Masuku , BP769 Franceville, Gabon.
Org Lett. 2017 Nov 17;19(22):6180-6183. doi: 10.1021/acs.orglett.7b03098. Epub 2017 Nov 7.
Pleiokomenines A and B (1 and 2), first examples of dimeric aspidofractinine alkaloids linked by a methylene bridge, were isolated from the stem bark of Pleiocarpa mutica. Their structures were elucidated by a combination of spectroscopic analyses and semisynthetic derivatization of pleiocarpinine (3) and a formaldehyde equivalent mediated by scandium trifluoromethanesulfonate. Pleiokomenines A (1) and B (2) showed moderate antiplasmodial activities in the micromolar range against the FcB1 strain.
从 Pleiocarpa mutica 的茎皮中分离得到了 Pleiokomenines A 和 B（1 和 2），它们是首例通过亚甲基桥连接的二聚体 aspidofractinine 生物碱。通过光谱分析和半合成衍生化 pleiocarpinine（3）以及 scandium trifluoromethanesulfonate 介导的甲醛当量的组合，阐明了它们的结构。Pleiokomenines A（1）和 B（2）对 FcB1 株显示出中等的抗疟活性，在微摩尔范围内。
