Équipe "Pharmacognosie-Chimie des Substances Naturelles" BioCIS , Université Paris-Sud, CNRS, Université Paris-Saclay , 5 rue J.-B. Clément , 92290 Châtenay-Malabry , France.
Laboratoire de Microbiologie , Université des Sciences et Techniques de Masuku , BP769 Franceville , Gabon.
Org Lett. 2018 Oct 19;20(20):6596-6600. doi: 10.1021/acs.orglett.8b02961. Epub 2018 Oct 10.
Theionbrunonines A and B (1 and 2), the first examples of monoterpene bisindole alkaloids linked by a thioether bridge, were isolated from the stems of Mostuea brunonis, guided by a molecular networking-based dereplication strategy. Their structures were elucidated by a combination of spectroscopic data and ECD calculations. A plausible biosynthetic pathway for 1 and 2 was postulated. Theionbrunonines A and B (1 and 2) showed moderate antiplasmodial activities in the micromolar range against the strain FcB1 of Plasmodium falciparum and no cytotoxic activity against the MRC-5 cell line at 20 μM.
硫醚桥连接的单萜双吲哚生物碱硫堇布鲁宁 A 和 B（1 和 2）是从 Mostuea brunonis 的茎中分离出来的，这是基于分子网络去重策略指导的。通过光谱数据分析和 ECD 计算相结合的方法，阐明了它们的结构。提出了 1 和 2 的可能生物合成途径。硫堇布鲁宁 A 和 B（1 和 2）在微摩尔范围内对 Plasmodium falciparum 的 FcB1 菌株表现出中等的抗疟活性，在 20 μM 时对 MRC-5 细胞系没有细胞毒性。
