RFAM 13.0：转向以基因组为中心的非编码 RNA 家族资源
Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families.
机构信息
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Systems Biology Graduate Program, Harvard University, Cambridge, MA 02138, USA.
出版信息
Nucleic Acids Res. 2018 Jan 4;46(D1):D335-D342. doi: 10.1093/nar/gkx1038.
The Rfam database is a collection of RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. In this paper we introduce Rfam release 13.0, which switches to a new genome-centric approach that annotates a non-redundant set of reference genomes with RNA families. We describe new web interface features including faceted text search and R-scape secondary structure visualizations. We discuss a new literature curation workflow and a pipeline for building families based on RNAcentral. There are 236 new families in release 13.0, bringing the total number of families to 2687. The Rfam website is http://rfam.org.
Rfam 数据库是一个 RNA 家族集合，每个家族都由一个多重序列比对、一个共识二级结构和一个协方差模型表示。在本文中，我们介绍了 Rfam 版本 13.0，它采用了一种新的以基因组为中心的方法，用 RNA 家族注释非冗余的一组参考基因组。我们描述了新的 Web 界面功能，包括分面文本搜索和 R-scape 二级结构可视化。我们讨论了一个新的文献整理工作流程和一个基于 RNAcentral 的家族构建管道。在版本 13.0 中有 236 个新家族，使家族总数达到 2687 个。Rfam 网站是 http://rfam.org。
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