European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Systems Biology Graduate Program, Harvard University, Cambridge, MA 02138, USA.
Nucleic Acids Res. 2018 Jan 4;46(D1):D335-D342. doi: 10.1093/nar/gkx1038.
The Rfam database is a collection of RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. In this paper we introduce Rfam release 13.0, which switches to a new genome-centric approach that annotates a non-redundant set of reference genomes with RNA families. We describe new web interface features including faceted text search and R-scape secondary structure visualizations. We discuss a new literature curation workflow and a pipeline for building families based on RNAcentral. There are 236 new families in release 13.0, bringing the total number of families to 2687. The Rfam website is http://rfam.org.
Rfam 数据库是一个 RNA 家族集合，每个家族都由一个多重序列比对、一个共识二级结构和一个协方差模型表示。在本文中，我们介绍了 Rfam 版本 13.0，它采用了一种新的以基因组为中心的方法，用 RNA 家族注释非冗余的一组参考基因组。我们描述了新的 Web 界面功能，包括分面文本搜索和 R-scape 二级结构可视化。我们讨论了一个新的文献整理工作流程和一个基于 RNAcentral 的家族构建管道。在版本 13.0 中有 236 个新家族，使家族总数达到 2687 个。Rfam 网站是 http://rfam.org。
