Surveillance and Reporting, C-MORE, CancerControl Alberta, Alberta Health Services, Edmonton and Calgary, AB, Canada.
Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Eur J Public Health. 2018 Apr 1;28(2):348-352. doi: 10.1093/eurpub/ckx195.
Breast cancer is the most commonly diagnosed cancer and the second most common cause of cancer deaths for women. In the present study, we examined the trend of premature mortality due to breast cancer among Canadian women from 1980 through 2010 and proposed a new measure of lifespan shortening.
Mortality data for female breast cancer was obtained from the World Health Organization mortality database. Years of life lost (YLL) was estimated using Canadian life tables. Average lifespan shortened (ALSS) that is calculated and expressed by a ratio of YLL relative to expected lifespan.
Over this study period, age-standardized rates of breast cancer mortality adjusted to World Standard Population decreased by 40% from 23.2 to 14.2 per 100 000 women. The adjusted YLL rates fell from 5.3 years per 1000 women to 3.3 years. On average women with breast cancer died 20.8 years prior to expected death in 1980 and 18.3 years early in 2010. A novel measure of lifespan shortening, the ALSS decreased from one-fourth of the lifespan in 1980 to one-fifth in 2010.
Our study reports that among Canadian women with breast cancer, a smaller proportion of life was lost on average at the end of the study period. The 'life lost' measures presented in this study would be useful tools to monitor the pattern of premature mortality for chronic conditions. These measures gauge the effectiveness of the health system with respect to early detection and treatment.
乳腺癌是最常见的女性癌症，也是女性癌症死亡的第二大常见原因。在本研究中，我们考察了 1980 年至 2010 年期间加拿大女性乳腺癌过早死亡率的趋势，并提出了一种衡量寿命缩短的新方法。
从世界卫生组织死亡率数据库中获取女性乳腺癌死亡率数据。使用加拿大生命表估计生命损失年数（YLL）。平均寿命缩短（ALSS）是通过 YLL 与预期寿命的比值计算和表示的。
在研究期间，按世界标准人口调整的乳腺癌死亡率标准化年龄比从每 10 万妇女 23.2 例降至 14.2 例，下降了 40%。调整后的 YLL 率从每 1000 名妇女 5.3 年降至 3.3 年。平均而言，1980 年患有乳腺癌的女性比预期死亡提前 20.8 年死亡，2010 年提前 18.3 年。衡量寿命缩短的一种新方法，即 ALSS，从 1980 年的四分之一降至 2010 年的五分之一。
本研究报告称，在加拿大患有乳腺癌的女性中，在研究期末平均丧失的生命比例较小。本研究中提出的“生命损失”衡量标准将是监测慢性疾病过早死亡率模式的有用工具。这些措施衡量了卫生系统在早期发现和治疗方面的效果。
