Fedele L, Acaia B, Parazzini F, Ricciardiello O, Candiani G B
1st Clnica Ostetrica e Ginecologica, Università di Milano, Italy.
Obstet Gynecol. 1989 Feb;73(2):206-8.
The association between spontaneous abortion and ectopic pregnancy was evaluated in a case-control study conducted on 161 women (cases) with recurrent spontaneous abortions (two or more consecutive spontaneous abortions) and 170 control subjects who delivered normal infants. The risk of ectopic pregnancy in women with a history of recurrent spontaneous abortion was about fourfold that of controls (relative risk adjusted for age and number of pregnancies = 4.3; 95% confidence interval 1.4-14.7). This association was confirmed by comparing the observed number of extrauterine pregnancies in women with recurrent spontaneous abortions with the expected number computed from regional data on the frequency of ectopic pregnancies; the estimated relative risk was 3.7, with a 95% confidence interval of 2.2-7.0. The present report found an association between spontaneous abortions and ectopic pregnancies, suggesting some common risk/etiologic factors for these two reproductive failures.
在一项病例对照研究中，对161名复发性自然流产（连续两次或更多次自然流产）的女性（病例组）和170名分娩正常婴儿的对照对象进行了自然流产与异位妊娠之间关联的评估。有复发性自然流产史的女性发生异位妊娠的风险约为对照组的四倍（根据年龄和妊娠次数调整后的相对风险=4.3；95%置信区间1.4 - 14.7）。通过将复发性自然流产女性中观察到的宫外妊娠数与根据区域异位妊娠频率数据计算出的预期数进行比较，证实了这种关联；估计的相对风险为3.7，95%置信区间为2.2 - 7.0。本报告发现自然流产与异位妊娠之间存在关联，提示这两种生殖失败存在一些共同的风险/病因因素。
