伊朗伊斯法罕帕金森病患者非运动症状及其对生活质量影响的评估。
Evaluation of non-motor symptoms and their impact on quality of life in patients with Parkinson's disease, Isfahan, Iran.
作者信息
Salari Mehri, Chitsaz Ahmad, Etemadifar Masoud, Najafi Mohammad Reza, Mirmosayyeb Omid, Bemanalizadeh Maryam, Panahi Fatemeh, Mirzajani Hosna
机构信息
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Iran J Neurol. 2017 Jul 6;16(3):118-124.
Parkinson's disease (PD) is diagnosed on the basis of motor symptoms, but non-motor symptoms (NMS) have high prevalence in PD and often antecede motor symptoms for years and cause severe disability. This study was conducted to determine the prevalence of NMS in patients with PD. This cross-sectional study was performed in Isfahan, Iran, on patients with PD. The prevalence of NMS was evaluated by the NMS questionnaire, the NMS scale, and Parkinson's disease questionnaire-39 (PDQ-39). The Mini-Mental Status Examination (MMSE) was used for assessing cognition. A total of 81 patients, including 60 men and 21 women, were recruited for this study. The prevalence of NMS was 100%, and the most commonly reported symptom was fatigue (87.7%); there was a strong correlation between NMS and the quality of life (QOL) of patients with PD (P < 0.001). This study showed that NMS are highly prevalent in the PD population and adversely affect QOL in these patients. Early diagnosis and treatment can improve QOL and can help in disability management of patients with PD.
帕金森病（PD）是根据运动症状来诊断的，但非运动症状（NMS）在帕金森病患者中普遍存在，且常常在运动症状出现前数年就已存在，并导致严重残疾。本研究旨在确定帕金森病患者中非运动症状的患病率。这项横断面研究在伊朗伊斯法罕对帕金森病患者进行。通过非运动症状问卷、非运动症状量表和帕金森病问卷-39（PDQ-39）对非运动症状的患病率进行评估。使用简易精神状态检查表（MMSE）评估认知功能。本研究共招募了81名患者，其中包括60名男性和21名女性。非运动症状的患病率为100%，最常报告的症状是疲劳（87.7%）；帕金森病患者的非运动症状与生活质量（QOL）之间存在很强的相关性（P < 0.001）。本研究表明，非运动症状在帕金森病患者群体中高度普遍，并对这些患者的生活质量产生不利影响。早期诊断和治疗可改善生活质量，并有助于帕金森病患者的残疾管理。
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