Karri Madhavi, Ramasamy Balakrishnan, Kalidoss Ramadoss
Department of Neurology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
Department of Neurology, Sri Ramakrishna Hospitals, Coimbatore, Tamil Nadu, India.
Ann Indian Acad Neurol. 2020 May-Jun;23(3):270-274. doi: 10.4103/aian.AIAN_10_19. Epub 2020 Jun 10.
Parkinson's disease (PD) is a neurodegenerative disease characterized by traditional motor features. Non-motor symptoms (NMS) are also seen in PD, which inevitably emerge through the disease progression and are often under-recognized and untargeted.
We studied the prevalence of NMS in PD and their impact on health-related quality of life (HRQoL).
A cross-sectional observational study from January 2017 to July 2017 of PD patients ( = 100) was done. NMS and HRQoL are measured using NMS scoring scale; PD questionnaire-39 and Hoehn and Yahr scale, respectively. Motor symptoms were assessed using scales for outcome in Parkinson's disease (SCoPA) - motor scoring scale.
Descriptive statistics calculated for NMS' prevalence. Continuous variables were assessed by two-tailed -test and discrete and categorical variables by chi-square test. Multiple linear regression analysis was done among scoring scales to identify the influence on 39-item Parkinson's disease questionnaire (PDQ-39) scoring scale. All statistical data collected are analyzed with SSPS software version- 20 for windows.
In 100 study population, 66 were males and 34 females. The mean age was 68.35 years and median onset of duration of PD was 3.49 with 64.6% on treatment. Fatigue, pain, and lightheadedness were more prevalent NMS with 78%, 75%, and 69%, respectively. With regression analysis, strongest predictor was NMSS score ( = 0.000), with each unit increase, it is associated with nearly 0.65 increase in PDQ-39 score.
Though motor symptoms define the disease, NMS have a larger impact on HRQoL in PD and on caregiver's life. Understanding the pattern and effect of NMS is needed for targeted treatment strategies.
帕金森病（PD）是一种以传统运动特征为特点的神经退行性疾病。非运动症状（NMS）在帕金森病中也较为常见，这些症状会随着疾病进展不可避免地出现，且常常未得到充分认识和针对性治疗。
我们研究了帕金森病中非运动症状的患病率及其对健康相关生活质量（HRQoL）的影响。
对2017年1月至2017年7月的帕金森病患者（n = 100）进行了一项横断面观察性研究。分别使用非运动症状评分量表、帕金森病问卷-39和霍恩与雅尔分级量表来测量非运动症状和健康相关生活质量。使用帕金森病结局量表（SCoPA）-运动评分量表评估运动症状。
计算非运动症状患病率的描述性统计数据。连续变量通过双侧t检验进行评估，离散和分类变量通过卡方检验进行评估。在各评分量表之间进行多元线性回归分析，以确定对39项帕金森病问卷（PDQ-39）评分量表的影响。所有收集到的统计数据均使用适用于Windows的SPSS软件版本20进行分析。
在100名研究对象中，男性66名，女性34名。平均年龄为68.35岁，帕金森病发病的中位病程为3.49年，64.6%的患者正在接受治疗。疲劳、疼痛和头晕是非运动症状中较为常见的症状，患病率分别为78%、75%和69%。通过回归分析，最强的预测因素是非运动症状评分量表（NMSS）得分（P = 0.000），每增加一个单位，与帕金森病问卷-39得分增加近0.65相关。
虽然运动症状是该疾病的定义特征，但非运动症状对帕金森病患者的健康相关生活质量以及照料者的生活有更大影响。需要了解非运动症状的模式和影响，以制定针对性的治疗策略。
