来自红曲发酵大米的四种新型莫纳可林类似物。
Four new monacolin analogs from Monascus purpureus-fermented rice.
作者信息
Zhang Bo, Liu Tian-Xi, Wang A-Li, Li Jin-Jie, Wang Xin, Luan Na, Ji Lin-Lin, Shang Xiao-Ya
机构信息
a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
b Nephrology Department , The First Hospital of Lanzhou University , Lanzhou 730000 , China.
出版信息
J Asian Nat Prod Res. 2018 Mar;20(3):209-216. doi: 10.1080/10286020.2017.1396978. Epub 2017 Nov 8.
Four new monacolin analogs, monacolin T (1), monacolin U (2) 6a-O-methyl-4,6-dihydromonacolin L (3), and 6a-O-ethyl-4,6-dihydromonacolin L (4) were isolated from the ethanolic extract of Monascus purpureus-fermented rice. Their structures were determined by a combination of 1D, 2D NMR experiments (H-HCOSY, HSQC, HMBC, and ROESY), and mass spectrometry. In vitro cytotoxic assay, all compounds were inactive at the concentration of 10 µM.
从紫红红曲发酵大米的乙醇提取物中分离出四种新的莫纳可林类似物，即莫纳可林T（1）、莫纳可林U（2）、6a - O - 甲基 - 4,6 - 二氢莫纳可林L（3）和6a - O - 乙基 - 4,6 - 二氢莫纳可林L（4）。通过一维、二维核磁共振实验（H - HCOSY、HSQC、HMBC和ROESY）以及质谱联用确定了它们的结构。体外细胞毒性试验表明，所有化合物在10 μM浓度下均无活性。
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